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Diagnostic Power of 24S-Hydroxycholesterol in Cerebrospinal Fluid: Candidate Marker of Brain Health

Leoni, Valerio ; Solomon, Alina ; Lovgren-Sandblom, Anita ; Minthon, Lennart LU ; Blennow, Kaj ; Hansson, Oskar LU orcid ; Wahlund, Lars-Olof ; Kivipelto, Miia and Bjorkhem, Ingemar (2013) In Journal of Alzheimer's Disease 36(4). p.739-747
Abstract
We evaluated the diagnostic potential of 24S-hydroxycholesterol (24OHC) in cerebrospinal fluid. At a memory clinic, we investigated subjects with subjective cognitive impairment (SCI, n = 33), mild cognitive impairment (MCI) patients (n = 27), MCI patients with later progression into Alzheimer dementia at follow up (n = 10), and patients with AD (n = 24). We also had a control group of healthy volunteers who did not later develop cognitive problems (n = 13). The fraction of the population with pathological levels of 24OHC was 8% in controls, 34% in SCI, 37% in MCI, 80% in MCI with progression, and 42% in AD. The corresponding fractions for T-tau, P-tau, and A beta(42) were lower in the case of SCI and MCI but higher in the case of controls... (More)
We evaluated the diagnostic potential of 24S-hydroxycholesterol (24OHC) in cerebrospinal fluid. At a memory clinic, we investigated subjects with subjective cognitive impairment (SCI, n = 33), mild cognitive impairment (MCI) patients (n = 27), MCI patients with later progression into Alzheimer dementia at follow up (n = 10), and patients with AD (n = 24). We also had a control group of healthy volunteers who did not later develop cognitive problems (n = 13). The fraction of the population with pathological levels of 24OHC was 8% in controls, 34% in SCI, 37% in MCI, 80% in MCI with progression, and 42% in AD. The corresponding fractions for T-tau, P-tau, and A beta(42) were lower in the case of SCI and MCI but higher in the case of controls and AD. In case of MCI with progression, the fraction of pathological levels of 24OHC and A beta(42) were 80% and 63% respectively. We also studied a population of old healthy subjects age 75-99 years (n = 25). The fraction of individuals in this population with pathological levels of 24OHC was 0% whereas the fraction of individuals with pathological level of at least one of the other three biomarkers was 40%. The diagnostic power of 24OHC in cerebrospinal fluid seems to be similar to or lower than that of the established biomarkers T-tau, P-tau, and A beta(42) in the diagnosis of established AD. Our data suggest that 24OHC may be more sensitive than the classical biomarkers in an early phase of the neurodegenerative process and a better marker for "brain health" in old age. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, ApoE, biomarker, cholesterol, cognitive decline, mass, spectrometry, neurodegenerative diseases, oxysterols
in
Journal of Alzheimer's Disease
volume
36
issue
4
pages
739 - 747
publisher
IOS Press
external identifiers
  • wos:000322738000011
  • scopus:84881440031
  • pmid:23666171
ISSN
1387-2877
DOI
10.3233/JAD-130035
language
English
LU publication?
yes
id
76fb9185-2e85-449f-9aa3-4a03c0f8edd0 (old id 4042609)
date added to LUP
2016-04-01 11:07:20
date last changed
2022-05-06 04:40:19
@article{76fb9185-2e85-449f-9aa3-4a03c0f8edd0,
  abstract     = {{We evaluated the diagnostic potential of 24S-hydroxycholesterol (24OHC) in cerebrospinal fluid. At a memory clinic, we investigated subjects with subjective cognitive impairment (SCI, n = 33), mild cognitive impairment (MCI) patients (n = 27), MCI patients with later progression into Alzheimer dementia at follow up (n = 10), and patients with AD (n = 24). We also had a control group of healthy volunteers who did not later develop cognitive problems (n = 13). The fraction of the population with pathological levels of 24OHC was 8% in controls, 34% in SCI, 37% in MCI, 80% in MCI with progression, and 42% in AD. The corresponding fractions for T-tau, P-tau, and A beta(42) were lower in the case of SCI and MCI but higher in the case of controls and AD. In case of MCI with progression, the fraction of pathological levels of 24OHC and A beta(42) were 80% and 63% respectively. We also studied a population of old healthy subjects age 75-99 years (n = 25). The fraction of individuals in this population with pathological levels of 24OHC was 0% whereas the fraction of individuals with pathological level of at least one of the other three biomarkers was 40%. The diagnostic power of 24OHC in cerebrospinal fluid seems to be similar to or lower than that of the established biomarkers T-tau, P-tau, and A beta(42) in the diagnosis of established AD. Our data suggest that 24OHC may be more sensitive than the classical biomarkers in an early phase of the neurodegenerative process and a better marker for "brain health" in old age.}},
  author       = {{Leoni, Valerio and Solomon, Alina and Lovgren-Sandblom, Anita and Minthon, Lennart and Blennow, Kaj and Hansson, Oskar and Wahlund, Lars-Olof and Kivipelto, Miia and Bjorkhem, Ingemar}},
  issn         = {{1387-2877}},
  keywords     = {{Aging; ApoE; biomarker; cholesterol; cognitive decline; mass; spectrometry; neurodegenerative diseases; oxysterols}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{739--747}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's Disease}},
  title        = {{Diagnostic Power of 24S-Hydroxycholesterol in Cerebrospinal Fluid: Candidate Marker of Brain Health}},
  url          = {{http://dx.doi.org/10.3233/JAD-130035}},
  doi          = {{10.3233/JAD-130035}},
  volume       = {{36}},
  year         = {{2013}},
}