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Pharmacokinetic digital phantoms for accuracy assessment of image-based dosimetry in (177)Lu-DOTATATE peptide receptor radionuclide therapy.

Brolin, Gustav LU ; Gustafsson, Johan Ruben LU orcid ; Ljungberg, Michael LU orcid and Sjögreen Gleisner, Katarina LU (2015) In Physics in Medicine and Biology 60(15). p.6131-6149
Abstract
Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms corresponding to patients treated with (177)Lu-DOTATATE. Three individual voxel phantoms from the XCAT population were generated and assigned a dynamic activity distribution based on a compartment model for (177)Lu-DOTATATE, designed specifically for this purpose. The compartment model was fitted to time-activity data from 10 patients, primarily acquired... (More)
Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms corresponding to patients treated with (177)Lu-DOTATATE. Three individual voxel phantoms from the XCAT population were generated and assigned a dynamic activity distribution based on a compartment model for (177)Lu-DOTATATE, designed specifically for this purpose. The compartment model was fitted to time-activity data from 10 patients, primarily acquired using quantitative scintillation camera imaging. S values for all phantom source-target combinations were calculated based on Monte-Carlo simulations. Combining the S values and time-activity curves, reference values of the absorbed dose to the phantom kidneys, liver, spleen, tumours and whole-body were calculated. The phantoms were used in a virtual dosimetry study, using Monte-Carlo simulated gamma-camera images and conventional methods for absorbed-dose calculations. The characteristics of the SPECT and WB planar images were found to well represent those of real patient images, capturing the difficulties present in image-based dosimetry. The phantoms are expected to be useful for further studies and optimisation of clinical dosimetry in (177)Lu PRRT. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
60
issue
15
pages
6131 - 6149
publisher
IOP Publishing
external identifiers
  • pmid:26215085
  • wos:000361040900025
  • scopus:84938118063
  • pmid:26215085
ISSN
1361-6560
DOI
10.1088/0031-9155/60/15/6131
language
English
LU publication?
yes
id
13ddd1e2-0335-4336-9960-5a66f0807b68 (old id 7703965)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26215085?dopt=Abstract
date added to LUP
2016-04-01 10:34:35
date last changed
2025-01-14 18:12:09
@article{13ddd1e2-0335-4336-9960-5a66f0807b68,
  abstract     = {{Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms corresponding to patients treated with (177)Lu-DOTATATE. Three individual voxel phantoms from the XCAT population were generated and assigned a dynamic activity distribution based on a compartment model for (177)Lu-DOTATATE, designed specifically for this purpose. The compartment model was fitted to time-activity data from 10 patients, primarily acquired using quantitative scintillation camera imaging. S values for all phantom source-target combinations were calculated based on Monte-Carlo simulations. Combining the S values and time-activity curves, reference values of the absorbed dose to the phantom kidneys, liver, spleen, tumours and whole-body were calculated. The phantoms were used in a virtual dosimetry study, using Monte-Carlo simulated gamma-camera images and conventional methods for absorbed-dose calculations. The characteristics of the SPECT and WB planar images were found to well represent those of real patient images, capturing the difficulties present in image-based dosimetry. The phantoms are expected to be useful for further studies and optimisation of clinical dosimetry in (177)Lu PRRT.}},
  author       = {{Brolin, Gustav and Gustafsson, Johan Ruben and Ljungberg, Michael and Sjögreen Gleisner, Katarina}},
  issn         = {{1361-6560}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{6131--6149}},
  publisher    = {{IOP Publishing}},
  series       = {{Physics in Medicine and Biology}},
  title        = {{Pharmacokinetic digital phantoms for accuracy assessment of image-based dosimetry in (177)Lu-DOTATATE peptide receptor radionuclide therapy.}},
  url          = {{https://lup.lub.lu.se/search/files/1961323/8867491.pdf}},
  doi          = {{10.1088/0031-9155/60/15/6131}},
  volume       = {{60}},
  year         = {{2015}},
}