Environmental Hexachlorobenzene exposure and human male reproductive function.
(2015) In Reproductive Toxicology 58(Jul 22). p.8-14- Abstract
- Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3 ng/g lipid) and Greenland (79.0 ng/g lipid) compared to Poland (14.2 ng/g lipid). Sex Hormone Binding Globulin (SHBG) and Free Androgen Index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in... (More)
- Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3 ng/g lipid) and Greenland (79.0 ng/g lipid) compared to Poland (14.2 ng/g lipid). Sex Hormone Binding Globulin (SHBG) and Free Androgen Index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in environmental HCB exposure levels shows a positive association for SHBG and negative association for FAI with high serum levels of HCB in fertile men, but without major consequences for semen quality and the Inuit study population. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7720745
- author
- Specht, Ina Olmer ; Bonde, Jens Peter Ellekilde ; Toft, Gunnar ; Giwercman, Aleksander LU ; Spanò, Marcello ; Bizzaro, Davide ; Manicardi, Gian Carlo ; Jönsson, Bo A LU and Robbins, Wendie A
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Reproductive Toxicology
- volume
- 58
- issue
- Jul 22
- pages
- 8 - 14
- publisher
- Elsevier
- external identifiers
-
- pmid:26210665
- wos:000367559600002
- scopus:84939213235
- pmid:26210665
- ISSN
- 1873-1708
- DOI
- 10.1016/j.reprotox.2015.07.074
- language
- English
- LU publication?
- yes
- id
- d8281c44-01f2-4bea-94c8-3ea79bd5ecd4 (old id 7720745)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26210665?dopt=Abstract
- date added to LUP
- 2016-04-01 11:08:06
- date last changed
- 2022-04-28 07:38:22
@article{d8281c44-01f2-4bea-94c8-3ea79bd5ecd4, abstract = {{Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3 ng/g lipid) and Greenland (79.0 ng/g lipid) compared to Poland (14.2 ng/g lipid). Sex Hormone Binding Globulin (SHBG) and Free Androgen Index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in environmental HCB exposure levels shows a positive association for SHBG and negative association for FAI with high serum levels of HCB in fertile men, but without major consequences for semen quality and the Inuit study population.}}, author = {{Specht, Ina Olmer and Bonde, Jens Peter Ellekilde and Toft, Gunnar and Giwercman, Aleksander and Spanò, Marcello and Bizzaro, Davide and Manicardi, Gian Carlo and Jönsson, Bo A and Robbins, Wendie A}}, issn = {{1873-1708}}, language = {{eng}}, number = {{Jul 22}}, pages = {{8--14}}, publisher = {{Elsevier}}, series = {{Reproductive Toxicology}}, title = {{Environmental Hexachlorobenzene exposure and human male reproductive function.}}, url = {{http://dx.doi.org/10.1016/j.reprotox.2015.07.074}}, doi = {{10.1016/j.reprotox.2015.07.074}}, volume = {{58}}, year = {{2015}}, }