Advanced

GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.

Rehn, Martin LU ; Krarup, Peter-Martin; Christensen, Lise H; Seidelin, Jakob B; Ågren, Magnus S and Syk, Ingvar LU (2015) In Surgical Infections 16(6). p.702-708
Abstract
Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Surgical Infections
volume
16
issue
6
pages
702 - 708
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:26171681
  • wos:000365530800007
  • scopus:84948694543
ISSN
1557-8674
DOI
10.1089/sur.2014.248
language
English
LU publication?
yes
id
57f868cc-4c35-489b-b705-91f746c1f445 (old id 7744557)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26171681?dopt=Abstract
date added to LUP
2015-08-10 01:11:19
date last changed
2017-08-27 03:45:12
@article{57f868cc-4c35-489b-b705-91f746c1f445,
  abstract     = {Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.},
  author       = {Rehn, Martin and Krarup, Peter-Martin and Christensen, Lise H and Seidelin, Jakob B and Ågren, Magnus S and Syk, Ingvar},
  issn         = {1557-8674},
  language     = {eng},
  number       = {6},
  pages        = {702--708},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Surgical Infections},
  title        = {GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.},
  url          = {http://dx.doi.org/10.1089/sur.2014.248},
  volume       = {16},
  year         = {2015},
}