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Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

Melander, Olle LU ; Orho-Melander, Marju LU ; Manjer, Jonas LU ; Svensson, Thomas; Almgren, Peter LU ; Nilsson, Peter LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Borgquist, Signe LU and Hartmann, Oliver, et al. (2015) In Journal of Clinical Oncology 33(24). p.81-2632
Abstract
In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Oncology
volume
33
issue
24
pages
81 - 2632
publisher
American Society of Clinical Oncology
external identifiers
  • pmid:26169618
  • wos:000361655000011
  • scopus:84940521359
ISSN
1527-7755
DOI
10.1200/JCO.2014.59.7682
language
English
LU publication?
yes
id
7caf07cb-8d75-46fa-8423-3c3b586ad19c (old id 7749726)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26169618?dopt=Abstract
date added to LUP
2015-08-08 01:41:06
date last changed
2017-09-10 03:18:19
@article{7caf07cb-8d75-46fa-8423-3c3b586ad19c,
  abstract     = {In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.},
  author       = {Melander, Olle and Orho-Melander, Marju and Manjer, Jonas and Svensson, Thomas and Almgren, Peter and Nilsson, Peter and Engström, Gunnar and Hedblad, Bo and Borgquist, Signe and Hartmann, Oliver and Struck, Joachim and Bergmann, Andreas and Belting, Mattias},
  issn         = {1527-7755},
  language     = {eng},
  number       = {24},
  pages        = {81--2632},
  publisher    = {American Society of Clinical Oncology},
  series       = {Journal of Clinical Oncology},
  title        = {Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.},
  url          = {http://dx.doi.org/10.1200/JCO.2014.59.7682},
  volume       = {33},
  year         = {2015},
}