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Viremia during pregnancy and risk of childhood leukemia and lymphomas in the offspring: Nested case-control study.

Bzhalava, Davit LU ; Hultin, Emilie; Arroyo Mühr, Laila Sara; Ekström, Johanna LU ; Lehtinen, Matti; de Villiers, Ethel-Michele and Dillner, Joakim LU (2016) In International Journal of Cancer 138(9). p.2212-2220
Abstract
A possible role for infections of the pregnant mother in the development of childhood acute leukemias and lymphomas has been suggested. However, no specific infectious agent has been identified. Offspring of 74,000 mothers who had serum samples taken during pregnancy and stored in a large-scale biobank were followed up to the age of 15 years (750,000 person years) through over-generation linkages between the biobank files, the Swedish national population and cancer registers to identify incident leukemia/lymphoma cases in the offspring. First-trimester sera from mothers of 47 cases and 47 matched controls were retrieved and analyzed using next generation sequencing. Anelloviruses were the most common viruses detected, found in 37/47 cases... (More)
A possible role for infections of the pregnant mother in the development of childhood acute leukemias and lymphomas has been suggested. However, no specific infectious agent has been identified. Offspring of 74,000 mothers who had serum samples taken during pregnancy and stored in a large-scale biobank were followed up to the age of 15 years (750,000 person years) through over-generation linkages between the biobank files, the Swedish national population and cancer registers to identify incident leukemia/lymphoma cases in the offspring. First-trimester sera from mothers of 47 cases and 47 matched controls were retrieved and analyzed using next generation sequencing. Anelloviruses were the most common viruses detected, found in 37/47 cases and in 40/47 controls, respectively (OR: 0.6, 95% CI: 0.2-1.9). None of the detected viruses was associated with leukemia/lymphoma in the offspring. Viremia during pregnancy was common, but no association with leukemia/lymphoma risk in the offspring was found. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
138
issue
9
pages
2212 - 2220
publisher
John Wiley & Sons
external identifiers
  • pmid:26132655
  • scopus:84958953710
  • wos:000371161800016
ISSN
0020-7136
DOI
10.1002/ijc.29666
language
English
LU publication?
yes
id
2b9c3d00-53e2-4b40-a694-1521c5c1d09d (old id 7751147)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26132655?dopt=Abstract
date added to LUP
2015-08-01 21:47:19
date last changed
2017-10-22 04:55:47
@article{2b9c3d00-53e2-4b40-a694-1521c5c1d09d,
  abstract     = {A possible role for infections of the pregnant mother in the development of childhood acute leukemias and lymphomas has been suggested. However, no specific infectious agent has been identified. Offspring of 74,000 mothers who had serum samples taken during pregnancy and stored in a large-scale biobank were followed up to the age of 15 years (750,000 person years) through over-generation linkages between the biobank files, the Swedish national population and cancer registers to identify incident leukemia/lymphoma cases in the offspring. First-trimester sera from mothers of 47 cases and 47 matched controls were retrieved and analyzed using next generation sequencing. Anelloviruses were the most common viruses detected, found in 37/47 cases and in 40/47 controls, respectively (OR: 0.6, 95% CI: 0.2-1.9). None of the detected viruses was associated with leukemia/lymphoma in the offspring. Viremia during pregnancy was common, but no association with leukemia/lymphoma risk in the offspring was found.},
  author       = {Bzhalava, Davit and Hultin, Emilie and Arroyo Mühr, Laila Sara and Ekström, Johanna and Lehtinen, Matti and de Villiers, Ethel-Michele and Dillner, Joakim},
  issn         = {0020-7136},
  language     = {eng},
  number       = {9},
  pages        = {2212--2220},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Viremia during pregnancy and risk of childhood leukemia and lymphomas in the offspring: Nested case-control study.},
  url          = {http://dx.doi.org/10.1002/ijc.29666},
  volume       = {138},
  year         = {2016},
}