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Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

Shami, Annelie LU ; Tengryd, Christoffer LU ; Asciutto, Giuseppe LU ; Bengtsson, Eva LU ; Nilsson, Jan LU ; Hultgårdh, Anna LU and Goncalves, Isabel LU (2015) In Atherosclerosis 241(2). p.701-708
Abstract
The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Atherosclerosis
volume
241
issue
2
pages
701 - 708
publisher
Elsevier
external identifiers
  • pmid:26125412
  • wos:000360100700053
  • scopus:84932639797
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2015.06.023
language
English
LU publication?
yes
id
6fec904b-2f7c-4fff-b822-978a44f77529 (old id 7751417)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26125412?dopt=Abstract
date added to LUP
2015-08-01 20:32:44
date last changed
2017-01-01 03:18:59
@article{6fec904b-2f7c-4fff-b822-978a44f77529,
  abstract     = {The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.},
  author       = {Shami, Annelie and Tengryd, Christoffer and Asciutto, Giuseppe and Bengtsson, Eva and Nilsson, Jan and Hultgårdh, Anna and Goncalves, Isabel},
  issn         = {1879-1484},
  language     = {eng},
  number       = {2},
  pages        = {701--708},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.023},
  volume       = {241},
  year         = {2015},
}