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The Concept of Cancer Stem Cells : Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression

Tsochantaridis, Ilias ; Roupas, Angelos ; Mohlin, Sofie LU orcid ; Pappa, Aglaia and Voulgaridou, Georgia Persephoni (2023) In Life 13(1).
Abstract

Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity, which obstructs the efficient eradication of the tumor. Tumor heterogeneity is often associated with the presence of cancer stem cells (CSCs), a cancer cell sub-population possessing a panel of stem-like properties, such as a self-renewal ability and multipotency potential. CSCs are associated with enhanced chemoresistance due to the enhanced efflux of chemotherapeutic agents and the existence of powerful antioxidant and DNA damage repair mechanisms. The distinctive characteristics of CSCs make them ideal targets for clinical therapeutic approaches,... (More)

Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity, which obstructs the efficient eradication of the tumor. Tumor heterogeneity is often associated with the presence of cancer stem cells (CSCs), a cancer cell sub-population possessing a panel of stem-like properties, such as a self-renewal ability and multipotency potential. CSCs are associated with enhanced chemoresistance due to the enhanced efflux of chemotherapeutic agents and the existence of powerful antioxidant and DNA damage repair mechanisms. The distinctive characteristics of CSCs make them ideal targets for clinical therapeutic approaches, and the identification of efficient and specific CSCs biomarkers is of utmost importance. Aldehyde dehydrogenases (ALDHs) comprise a wide superfamily of metabolic enzymes that, over the last years, have gained increasing attention due to their association with stem-related features in a wide panel of hematopoietic malignancies and solid cancers. Aldehyde dehydrogenase 1B1 (ALDH1B1) is an isoform that has been characterized as a marker of colon cancer progression, while various studies suggest its importance in additional malignancies. Here, we review the basic concepts related to CSCs and discuss the potential role of ALDH1B1 in cancer development and its contribution to the CSC phenotype.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aldehyde dehydrogenase 1B1, aldehyde dehydrogenases, ALDHs, cancer, cancer stem cells, CSCs
in
Life
volume
13
issue
1
article number
197
publisher
MDPI AG
external identifiers
  • scopus:85146736379
  • pmid:36676146
ISSN
0024-3019
DOI
10.3390/life13010197
language
English
LU publication?
yes
id
775cae7a-8626-4ceb-b4ab-8b53426a0e21
date added to LUP
2023-02-13 14:13:34
date last changed
2024-06-28 01:01:05
@article{775cae7a-8626-4ceb-b4ab-8b53426a0e21,
  abstract     = {{<p>Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity, which obstructs the efficient eradication of the tumor. Tumor heterogeneity is often associated with the presence of cancer stem cells (CSCs), a cancer cell sub-population possessing a panel of stem-like properties, such as a self-renewal ability and multipotency potential. CSCs are associated with enhanced chemoresistance due to the enhanced efflux of chemotherapeutic agents and the existence of powerful antioxidant and DNA damage repair mechanisms. The distinctive characteristics of CSCs make them ideal targets for clinical therapeutic approaches, and the identification of efficient and specific CSCs biomarkers is of utmost importance. Aldehyde dehydrogenases (ALDHs) comprise a wide superfamily of metabolic enzymes that, over the last years, have gained increasing attention due to their association with stem-related features in a wide panel of hematopoietic malignancies and solid cancers. Aldehyde dehydrogenase 1B1 (ALDH1B1) is an isoform that has been characterized as a marker of colon cancer progression, while various studies suggest its importance in additional malignancies. Here, we review the basic concepts related to CSCs and discuss the potential role of ALDH1B1 in cancer development and its contribution to the CSC phenotype.</p>}},
  author       = {{Tsochantaridis, Ilias and Roupas, Angelos and Mohlin, Sofie and Pappa, Aglaia and Voulgaridou, Georgia Persephoni}},
  issn         = {{0024-3019}},
  keywords     = {{aldehyde dehydrogenase 1B1; aldehyde dehydrogenases; ALDHs; cancer; cancer stem cells; CSCs}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{MDPI AG}},
  series       = {{Life}},
  title        = {{The Concept of Cancer Stem Cells : Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression}},
  url          = {{http://dx.doi.org/10.3390/life13010197}},
  doi          = {{10.3390/life13010197}},
  volume       = {{13}},
  year         = {{2023}},
}