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Changes in the pattern of paracetamol use in the periconception period in a Danish cohort

Ersboll, Anne S.; Hedegaard, Mette; Damm, Peter; Johansen, Marianne; Tabor, Ann and Hegaard, Hanne Kristine LU (2015) In Acta Obstetricia et Gynecologica Scandinavica 94(8). p.898-903
Abstract
Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short- and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking,... (More)
Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short- and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index 25kg/m(2), unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Paracetamol, acetaminophen, pregnancy, antenatal care, prenatal care, exposure
in
Acta Obstetricia et Gynecologica Scandinavica
volume
94
issue
8
pages
898 - 903
publisher
Wiley-Blackwell
external identifiers
  • wos:000357983900013
  • scopus:84937073553
ISSN
1600-0412
DOI
10.1111/aogs.12667
language
English
LU publication?
yes
id
0fac7934-5e39-423c-8d77-731ec4f1ca4c (old id 7779716)
date added to LUP
2015-09-01 16:07:20
date last changed
2017-07-02 04:02:11
@article{0fac7934-5e39-423c-8d77-731ec4f1ca4c,
  abstract     = {Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short- and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index 25kg/m(2), unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation.},
  author       = {Ersboll, Anne S. and Hedegaard, Mette and Damm, Peter and Johansen, Marianne and Tabor, Ann and Hegaard, Hanne Kristine},
  issn         = {1600-0412},
  keyword      = {Paracetamol,acetaminophen,pregnancy,antenatal care,prenatal care,exposure},
  language     = {eng},
  number       = {8},
  pages        = {898--903},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Changes in the pattern of paracetamol use in the periconception period in a Danish cohort},
  url          = {http://dx.doi.org/10.1111/aogs.12667},
  volume       = {94},
  year         = {2015},
}