Irradiation in a flash : Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
(2017) In Radiotherapy and Oncology 124(3). p.365-369- Abstract
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/778171ab-d7fb-4dff-8868-786abbd029e1
- author
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- keywords
- Cognition's preservation, Flash-RT, Whole brain irradiation
- in
- Radiotherapy and Oncology
- volume
- 124
- issue
- 3
- pages
- 365 - 369
- publisher
- Elsevier
- external identifiers
-
- pmid:28545957
- scopus:85019639866
- ISSN
- 0167-8140
- DOI
- 10.1016/j.radonc.2017.05.003
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2017 Elsevier B.V.
- id
- 778171ab-d7fb-4dff-8868-786abbd029e1
- date added to LUP
- 2021-11-03 18:15:32
- date last changed
- 2024-07-14 23:54:32
@article{778171ab-d7fb-4dff-8868-786abbd029e1, abstract = {{<p>This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.</p>}}, author = {{Montay-Gruel, Pierre and Petersson, Kristoffer and Jaccard, Maud and Boivin, Gaël and Germond, Jean François and Petit, Benoit and Doenlen, Raphaël and Favaudon, Vincent and Bochud, François and Bailat, Claude and Bourhis, Jean and Vozenin, Marie Catherine}}, issn = {{0167-8140}}, keywords = {{Cognition's preservation; Flash-RT; Whole brain irradiation}}, language = {{eng}}, number = {{3}}, pages = {{365--369}}, publisher = {{Elsevier}}, series = {{Radiotherapy and Oncology}}, title = {{Irradiation in a flash : Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s}}, url = {{http://dx.doi.org/10.1016/j.radonc.2017.05.003}}, doi = {{10.1016/j.radonc.2017.05.003}}, volume = {{124}}, year = {{2017}}, }