Lung Function as a Risk Factor for Subarachnoid Hemorrhage: A Prospective Cohort Study.
(2012) In Stroke: a journal of cerebral circulation 43(10). p.2598-2598- Abstract
- BACKGROUND AND PURPOSE:
The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is not known. The association between lung function and incidence of SAH was investigated in a prospective cohort study.
METHODS: Between 1974 and 1992, 20 534 men and 7237 women (mean age, 44 years) were examined in a health screening program including spirometry. The incidence of SAH was studied during a mean follow-up of 26 years in relation to age- and height-standardized FEV(1), FVC, and... (More) - BACKGROUND AND PURPOSE:
The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is not known. The association between lung function and incidence of SAH was investigated in a prospective cohort study.
METHODS: Between 1974 and 1992, 20 534 men and 7237 women (mean age, 44 years) were examined in a health screening program including spirometry. The incidence of SAH was studied during a mean follow-up of 26 years in relation to age- and height-standardized FEV(1), FVC, and FEV(1)/FVC.
RESULTS:
One hundred forty-five subjects had a SAH (18.3 per 100 000 person-years in men and 26.5 per 100 000 person-years in women). The hazard ratio for SAH in the lowest compared to the highest quartile of FEV(1) and FEV(1)/FVC was 2.24 (95% CI, 1.32-3.81; P for trend=0.014) and 1.92 (95% CI, 1.14-3.23; P for trend=0.003), respectively, after adjustment for several confounding factors including smoking and hypertension. The results persisted when analysis was restricted to nonsmokers. FVC showed no significant association with incidence of SAH.
CONCLUSIONS:
Baseline lung function, expressed as low FEV(1) or FEV(1)/FVC, is a risk factor for SAH, independently of smoking. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3047718
- author
- Söderholm, Martin LU ; Zia, Elisabet LU ; Hedblad, Bo LU and Engström, Gunnar LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prospective study, forced vital capacity, epidemiology, forced expiratory volume, subarachnoid hemorrhage, spirometry
- in
- Stroke: a journal of cerebral circulation
- volume
- 43
- issue
- 10
- pages
- 2598 - 2598
- publisher
- American Heart Association
- external identifiers
-
- wos:000309258900021
- pmid:22871680
- scopus:84866744014
- pmid:22871680
- ISSN
- 1524-4628
- DOI
- 10.1161/STROKEAHA.112.658427
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Malmö (013027010), Cardio-vascular Epidemiology (013241610)
- id
- 77ad3de7-cdb0-46ba-ba08-7d0ca7aeb3ba (old id 3047718)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22871680?dopt=Abstract
- date added to LUP
- 2016-04-01 14:00:08
- date last changed
- 2022-01-27 22:17:05
@article{77ad3de7-cdb0-46ba-ba08-7d0ca7aeb3ba, abstract = {{BACKGROUND AND PURPOSE: <br/><br> The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is not known. The association between lung function and incidence of SAH was investigated in a prospective cohort study. <br/><br> <br/><br> METHODS: Between 1974 and 1992, 20 534 men and 7237 women (mean age, 44 years) were examined in a health screening program including spirometry. The incidence of SAH was studied during a mean follow-up of 26 years in relation to age- and height-standardized FEV(1), FVC, and FEV(1)/FVC. <br/><br> <br/><br> RESULTS: <br/><br> One hundred forty-five subjects had a SAH (18.3 per 100 000 person-years in men and 26.5 per 100 000 person-years in women). The hazard ratio for SAH in the lowest compared to the highest quartile of FEV(1) and FEV(1)/FVC was 2.24 (95% CI, 1.32-3.81; P for trend=0.014) and 1.92 (95% CI, 1.14-3.23; P for trend=0.003), respectively, after adjustment for several confounding factors including smoking and hypertension. The results persisted when analysis was restricted to nonsmokers. FVC showed no significant association with incidence of SAH. <br/><br> <br/><br> CONCLUSIONS: <br/><br> Baseline lung function, expressed as low FEV(1) or FEV(1)/FVC, is a risk factor for SAH, independently of smoking.}}, author = {{Söderholm, Martin and Zia, Elisabet and Hedblad, Bo and Engström, Gunnar}}, issn = {{1524-4628}}, keywords = {{prospective study; forced vital capacity; epidemiology; forced expiratory volume; subarachnoid hemorrhage; spirometry}}, language = {{eng}}, number = {{10}}, pages = {{2598--2598}}, publisher = {{American Heart Association}}, series = {{Stroke: a journal of cerebral circulation}}, title = {{Lung Function as a Risk Factor for Subarachnoid Hemorrhage: A Prospective Cohort Study.}}, url = {{http://dx.doi.org/10.1161/STROKEAHA.112.658427}}, doi = {{10.1161/STROKEAHA.112.658427}}, volume = {{43}}, year = {{2012}}, }