Pulseq-CEST : Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard
(2021) In Magnetic Resonance in Medicine 86(4). p.1845-1858- Abstract
PURPOSE: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.
METHODS: We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human-readable CEST protocols can be shared; (2) an open-source Bloch-McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be... (More)
PURPOSE: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.
METHODS: We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human-readable CEST protocols can be shared; (2) an open-source Bloch-McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be combined with any existing readout module.
RESULTS: The exact definition of the CEST preparation period, in combination with the flexible simulation, leads to a good match between simulations and measurements. The standard allowed finding consensus on three amide proton transfer-weighted protocols that could be compared in healthy subjects and a tumor patient. In addition, we could show coherent multisite results for a sophisticated CEST method, highlighting the benefits regarding protocol sharing and reproducibility.
CONCLUSION: With Pulseq-CEST, we provide a straightforward approach to standardize, share, simulate, and measure different CEST preparation schemes, which are inherently completely defined.
(Less)
- author
- organization
- publishing date
- 2021-05-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Magnetic Resonance in Medicine
- volume
- 86
- issue
- 4
- pages
- 1845 - 1858
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85105221734
- pmid:33961312
- ISSN
- 1522-2594
- DOI
- 10.1002/mrm.28825
- project
- Natural sugar as an MRI contrast agent for cancer diagnosis
- language
- English
- LU publication?
- yes
- id
- 77b2006f-83b5-4127-ae8b-ba9ebe5bfbe2
- date added to LUP
- 2021-05-15 07:27:18
- date last changed
- 2024-09-07 19:17:04
@article{77b2006f-83b5-4127-ae8b-ba9ebe5bfbe2, abstract = {{<p>PURPOSE: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.</p><p>METHODS: We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human-readable CEST protocols can be shared; (2) an open-source Bloch-McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be combined with any existing readout module.</p><p>RESULTS: The exact definition of the CEST preparation period, in combination with the flexible simulation, leads to a good match between simulations and measurements. The standard allowed finding consensus on three amide proton transfer-weighted protocols that could be compared in healthy subjects and a tumor patient. In addition, we could show coherent multisite results for a sophisticated CEST method, highlighting the benefits regarding protocol sharing and reproducibility.</p><p>CONCLUSION: With Pulseq-CEST, we provide a straightforward approach to standardize, share, simulate, and measure different CEST preparation schemes, which are inherently completely defined.</p>}}, author = {{Herz, Kai and Mueller, Sebastian and Perlman, Or and Zaitsev, Maxim and Knutsson, Linda and Sun, Phillip Zhe and Zhou, Jinyuan and van Zijl, Peter and Heinecke, Kerstin and Schuenke, Patrick and Farrar, Christian T and Schmidt, Manuel and Dörfler, Arnd and Scheffler, Klaus and Zaiss, Moritz}}, issn = {{1522-2594}}, language = {{eng}}, month = {{05}}, number = {{4}}, pages = {{1845--1858}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Magnetic Resonance in Medicine}}, title = {{Pulseq-CEST : Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard}}, url = {{http://dx.doi.org/10.1002/mrm.28825}}, doi = {{10.1002/mrm.28825}}, volume = {{86}}, year = {{2021}}, }