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Cardiac Microvascular Disease Quantified with CMR

Gyllenhammar, Tom LU (2021) In Lund University, Faculty of Medicine Doctoral Dissertation Series
Abstract
This thesis has investigated three different diagnoses where cardiac microvascular disease is suspected: hypertrophic cardiomyopathy (HCM), systemic sclerosis (SSc), and patients with suspected microvascular angina (MVA).

Study I of this thesis investigated patients with HCM. We investigated the myocardial perfusion (MP) using cardiac magnetic resonance imaging (CMR) in young patients with HCM or the risk of developing the disease. The investigation found that the patients had lower blood flow of the heart muscle than a reference group with healthy volunteers. This finding was interpreted as a sign of cardiac microvascular disease.

Study II investigated patients with SSc, which is a complex rheumatic disease with... (More)
This thesis has investigated three different diagnoses where cardiac microvascular disease is suspected: hypertrophic cardiomyopathy (HCM), systemic sclerosis (SSc), and patients with suspected microvascular angina (MVA).

Study I of this thesis investigated patients with HCM. We investigated the myocardial perfusion (MP) using cardiac magnetic resonance imaging (CMR) in young patients with HCM or the risk of developing the disease. The investigation found that the patients had lower blood flow of the heart muscle than a reference group with healthy volunteers. This finding was interpreted as a sign of cardiac microvascular disease.

Study II investigated patients with SSc, which is a complex rheumatic disease with multiorgan involvement. The investigation showed that the patients had lower blood flow through the heart muscle than a reference group with healthy volunteers. This finding was interpreted as a sign of cardiac microvascular disease.

Study III Investigated patients with suspected MVA. The investigation showed that these patients had lower global MP than a reference group of healthy volunteers, but not as low as another reference group with patients with known coronary artery disease. The finding was interpreted as a sign of cardiac microvascular disease in this group of patients.

Study IV aimed to collect reference values for coronary sinus (CS) flow derived global MP and to validate the method against a flow phantom. The study showed that global MP was lower in men than women, which needs to be recognized when interpreting a quantitative assessment of global MP. The study also showed that the CS flow method is accurate compared to a flow phantom (Less)
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author
supervisor
opponent
  • professor Schwitter, Jürg, Lausanne
organization
publishing date
type
Thesis
publication status
published
subject
keywords
cardiac microvascular disease, magnetic resonance imaging, microvascular dysfunction, hypertrohic cardiomyopathy, systemic sclerosis, microvascular angina
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
issue
2021:79
publisher
Lund University, Faculty of Medicine
defense location
Segerfalksalen, BMC A10, Sölvegatan 17 i Lund. Join by Zoom: https://lu-se.zoom.us/j/67326187603
defense date
2021-09-17 14:00:00
ISSN
1652-8220
ISBN
978-91-8021-085-0
project
Cardiac Microvascular Disease Quantified with CMR
language
English
LU publication?
yes
id
77f32b0e-6797-4c1d-8cc4-d0c70e2d0222
date added to LUP
2021-08-15 23:27:27
date last changed
2021-08-26 12:29:32
@phdthesis{77f32b0e-6797-4c1d-8cc4-d0c70e2d0222,
  abstract     = {{This thesis has investigated three different diagnoses where cardiac microvascular disease is suspected: hypertrophic cardiomyopathy (HCM), systemic sclerosis (SSc), and patients with suspected microvascular angina (MVA).<br/><br/>Study I of this thesis investigated patients with HCM. We investigated the myocardial perfusion (MP) using cardiac magnetic resonance imaging (CMR) in young patients with HCM or the risk of developing the disease. The investigation found that the patients had lower blood flow of the heart muscle than a reference group with healthy volunteers. This finding was interpreted as a sign of cardiac microvascular disease.<br/><br/>Study II investigated patients with SSc, which is a complex rheumatic disease with multiorgan involvement. The investigation showed that the patients had lower blood flow through the heart muscle than a reference group with healthy volunteers. This finding was interpreted as a sign of cardiac microvascular disease.<br/><br/>Study III Investigated patients with suspected MVA. The investigation showed that these patients had lower global MP than a reference group of healthy volunteers, but not as low as another reference group with patients with known coronary artery disease. The finding was interpreted as a sign of cardiac microvascular disease in this group of patients.<br/><br/>Study IV aimed to collect reference values for coronary sinus (CS) flow derived global MP and to validate the method against a flow phantom. The study showed that global MP was lower in men than women, which needs to be recognized when interpreting a quantitative assessment of global MP. The study also showed that the CS flow method is accurate compared to a flow phantom}},
  author       = {{Gyllenhammar, Tom}},
  isbn         = {{978-91-8021-085-0}},
  issn         = {{1652-8220}},
  keywords     = {{cardiac microvascular disease; magnetic resonance imaging; microvascular dysfunction; hypertrohic cardiomyopathy; systemic sclerosis; microvascular angina}},
  language     = {{eng}},
  number       = {{2021:79}},
  publisher    = {{Lund University, Faculty of Medicine}},
  school       = {{Lund University}},
  series       = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}},
  title        = {{Cardiac Microvascular Disease Quantified with CMR}},
  url          = {{https://lup.lub.lu.se/search/files/101272766/Tom_Gyllenhammar_web.pdf}},
  year         = {{2021}},
}