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Detecting the vulnerable plaque in patients.

Goncalves, Isabel LU ; den Ruijter, H; Nahrendorf, M and Pasterkamp, G (2015) In Journal of Internal Medicine 278(5). p.520-530
Abstract
Atherosclerosis is a systemic condition that eventually evolves into vulnerable plaques and cardiovascular events. Pathology studies reveal that rupture-prone atherosclerotic plaques have a distinct morphology, namely a thin, inflamed fibrous cap covering a large lipidic and necrotic core. With the fast development of imaging techniques in the last decades, detecting vulnerable plaques thereby identifying individuals at high risk for cardiovascular events has become of major interest. Yet, in current clinical practice, there is no routine use of any vascular imaging modality to assess plaque characteristics as each unique technique has its pros and cons. This review describes the techniques that may evolve into screening tool for the... (More)
Atherosclerosis is a systemic condition that eventually evolves into vulnerable plaques and cardiovascular events. Pathology studies reveal that rupture-prone atherosclerotic plaques have a distinct morphology, namely a thin, inflamed fibrous cap covering a large lipidic and necrotic core. With the fast development of imaging techniques in the last decades, detecting vulnerable plaques thereby identifying individuals at high risk for cardiovascular events has become of major interest. Yet, in current clinical practice, there is no routine use of any vascular imaging modality to assess plaque characteristics as each unique technique has its pros and cons. This review describes the techniques that may evolve into screening tool for the detection of the vulnerable plaque. Finally, it seems that plaque morphology has been changing in the last decades leading to a higher prevalence of 'stable' atherosclerotic plaques, possibly due to the implementation of primary prevention strategies or other approaches. Therefore, the nomenclature of vulnerable plaque lesions should be very carefully defined in all studies. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
278
issue
5
pages
520 - 530
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • pmid:26306911
  • wos:000363278500008
  • scopus:84944688084
ISSN
1365-2796
DOI
10.1111/joim.12414
language
English
LU publication?
yes
id
8f723b9e-b2b5-4663-b491-2d4a6ae26bfd (old id 7834496)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26306911?dopt=Abstract
date added to LUP
2015-09-07 19:38:33
date last changed
2017-11-12 03:11:40
@article{8f723b9e-b2b5-4663-b491-2d4a6ae26bfd,
  abstract     = {Atherosclerosis is a systemic condition that eventually evolves into vulnerable plaques and cardiovascular events. Pathology studies reveal that rupture-prone atherosclerotic plaques have a distinct morphology, namely a thin, inflamed fibrous cap covering a large lipidic and necrotic core. With the fast development of imaging techniques in the last decades, detecting vulnerable plaques thereby identifying individuals at high risk for cardiovascular events has become of major interest. Yet, in current clinical practice, there is no routine use of any vascular imaging modality to assess plaque characteristics as each unique technique has its pros and cons. This review describes the techniques that may evolve into screening tool for the detection of the vulnerable plaque. Finally, it seems that plaque morphology has been changing in the last decades leading to a higher prevalence of 'stable' atherosclerotic plaques, possibly due to the implementation of primary prevention strategies or other approaches. Therefore, the nomenclature of vulnerable plaque lesions should be very carefully defined in all studies.},
  author       = {Goncalves, Isabel and den Ruijter, H and Nahrendorf, M and Pasterkamp, G},
  issn         = {1365-2796},
  language     = {eng},
  number       = {5},
  pages        = {520--530},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {Detecting the vulnerable plaque in patients.},
  url          = {http://dx.doi.org/10.1111/joim.12414},
  volume       = {278},
  year         = {2015},
}