Family history of venous thromboembolism as a risk factor and genetic research tool.
Zöller, Bengt LU
; Li, Xinjun
LU
; Ohlsson, Henrik
LU
; Ji, Jianguang
LU
; Sundquist, Jan
LU
and Sundquist, Kristina
LU
(2015)
In Thrombosis and Haemostasis
114(5).
p.890-900
- Abstract
- Familial clustering of venous thromboembolism (VTE) was described as far back as 1905 by Briggs. Although Egeberg discovered inherited deficiency of antithrombin in 1965, it was not until Dahlbäck discovered resistance to activated protein C in 1993 that it became clear that genetic factors are common risk factors of VTE. Several genes have been linked to familial aggregation of VTE and genome-wide association studies have found several novel gene loci. Still, it has been estimated that much of the heritability for VTE remains to be discovered. Family history (FH) of VTE is therefore still important to determine whether a patient has an increased genetic risk of VTE. FH has the potential to represent the sum of effects and interactions... (More)
- Familial clustering of venous thromboembolism (VTE) was described as far back as 1905 by Briggs. Although Egeberg discovered inherited deficiency of antithrombin in 1965, it was not until Dahlbäck discovered resistance to activated protein C in 1993 that it became clear that genetic factors are common risk factors of VTE. Several genes have been linked to familial aggregation of VTE and genome-wide association studies have found several novel gene loci. Still, it has been estimated that much of the heritability for VTE remains to be discovered. Family history (FH) of VTE is therefore still important to determine whether a patient has an increased genetic risk of VTE. FH has the potential to represent the sum of effects and interactions between environmental and genetic factors. In this article the design, methodology, results, clinical and genetic implications of FH studies of VTE are reviewed. FH in first-degree relatives (siblings and/or parents) is associated with a 2-3 times increased familial relative risk (FRR). However, the FRR is dependent on age, number of affected relatives, and presentation of VTE (provoked/unprovoked). Especially high familial risks are observed in individuals with two or more affected siblings (FFR> 50). However, the familial risk for recurrent VTE is much lower or non-significant. Moreover, FH of VTE appears mainly to be important for venous diseases (i. e. VTE and varicose veins). The familial associations with other diseases are weaker. In conclusion, FH of VTE is an important research tool and a clinically potential useful risk factor for VTE. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7834729
- author
- Zöller, Bengt
LU
; Li, Xinjun
LU
; Ohlsson, Henrik
LU
; Ji, Jianguang
LU
; Sundquist, Jan
LU
and Sundquist, Kristina
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis and Haemostasis
- volume
- 114
- issue
- 5
- pages
- 890 - 900
- publisher
- Schattauer GmbH
- external identifiers
-
- pmid:26305449
- wos:000364510100007
- scopus:84946559024
- pmid:26305449
- ISSN
- 0340-6245
- DOI
- 10.1160/TH15-04-0306
- language
- English
- LU publication?
- yes
- id
- 4e6ac2f9-5ef6-4e93-8c73-0e83d6c9cdc6 (old id 7834729)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26305449?dopt=Abstract
- date added to LUP
- 2016-04-01 13:29:41
- date last changed
- 2022-04-21 21:58:16
@article{4e6ac2f9-5ef6-4e93-8c73-0e83d6c9cdc6,
abstract = {{Familial clustering of venous thromboembolism (VTE) was described as far back as 1905 by Briggs. Although Egeberg discovered inherited deficiency of antithrombin in 1965, it was not until Dahlbäck discovered resistance to activated protein C in 1993 that it became clear that genetic factors are common risk factors of VTE. Several genes have been linked to familial aggregation of VTE and genome-wide association studies have found several novel gene loci. Still, it has been estimated that much of the heritability for VTE remains to be discovered. Family history (FH) of VTE is therefore still important to determine whether a patient has an increased genetic risk of VTE. FH has the potential to represent the sum of effects and interactions between environmental and genetic factors. In this article the design, methodology, results, clinical and genetic implications of FH studies of VTE are reviewed. FH in first-degree relatives (siblings and/or parents) is associated with a 2-3 times increased familial relative risk (FRR). However, the FRR is dependent on age, number of affected relatives, and presentation of VTE (provoked/unprovoked). Especially high familial risks are observed in individuals with two or more affected siblings (FFR> 50). However, the familial risk for recurrent VTE is much lower or non-significant. Moreover, FH of VTE appears mainly to be important for venous diseases (i. e. VTE and varicose veins). The familial associations with other diseases are weaker. In conclusion, FH of VTE is an important research tool and a clinically potential useful risk factor for VTE.}},
author = {{Zöller, Bengt and Li, Xinjun and Ohlsson, Henrik and Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina}},
issn = {{0340-6245}},
language = {{eng}},
number = {{5}},
pages = {{890--900}},
publisher = {{Schattauer GmbH}},
series = {{Thrombosis and Haemostasis}},
title = {{Family history of venous thromboembolism as a risk factor and genetic research tool.}},
url = {{http://dx.doi.org/10.1160/TH15-04-0306}},
doi = {{10.1160/TH15-04-0306}},
volume = {{114}},
year = {{2015}},
}