The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents.
(2016) In Addiction Biology 21(2). p.422-437- Abstract
- The incretin hormone, glucagon-like peptide 1 (GLP-1), regulates gastric emptying, glucose-dependent stimulation of insulin secretion and glucagon release, and GLP-1 analogs are therefore approved for treatment of type II diabetes. GLP-1 receptors are expressed in reward-related areas such as the ventral tegmental area and nucleus accumbens, and GLP-1 was recently shown to regulate several alcohol-mediated behaviors as well as amphetamine-induced, cocaine-induced and nicotine-induced reward. The present series of experiments were undertaken to investigate the effect of the GLP-1 receptor agonist, liraglutide, on several alcohol-related behaviors in rats that model different aspects of alcohol use disorder in humans. Acute liraglutide... (More)
- The incretin hormone, glucagon-like peptide 1 (GLP-1), regulates gastric emptying, glucose-dependent stimulation of insulin secretion and glucagon release, and GLP-1 analogs are therefore approved for treatment of type II diabetes. GLP-1 receptors are expressed in reward-related areas such as the ventral tegmental area and nucleus accumbens, and GLP-1 was recently shown to regulate several alcohol-mediated behaviors as well as amphetamine-induced, cocaine-induced and nicotine-induced reward. The present series of experiments were undertaken to investigate the effect of the GLP-1 receptor agonist, liraglutide, on several alcohol-related behaviors in rats that model different aspects of alcohol use disorder in humans. Acute liraglutide treatment suppressed the well-documented effects of alcohol on the mesolimbic dopamine system, namely alcohol-induced accumbal dopamine release and conditioned place preference in mice. In addition, acute administration of liraglutide prevented the alcohol deprivation effect and reduced alcohol intake in outbred rats, while repeated treatment of liraglutide decreased alcohol intake in outbred rats as well as reduced operant self-administration of alcohol in selectively bred Sardinian alcohol-preferring rats. Collectively, these data suggest that GLP-1 receptor agonists could be tested for treatment of alcohol dependence in humans. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7834982
- author
- Vallöf, Daniel ; Maccioni, Paola ; Colombo, Giancarlo ; Mandrapa, Minja ; Jörnulf, Julia Winsa ; Egecioglu, Emil LU ; Engel, Jörgen A and Jerlhag, Elisabet
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Addiction Biology
- volume
- 21
- issue
- 2
- pages
- 422 - 437
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:26303264
- scopus:84959217499
- wos:000371148700018
- pmid:26303264
- ISSN
- 1369-1600
- DOI
- 10.1111/adb.12295
- language
- English
- LU publication?
- yes
- id
- 2f16e633-6699-4bc1-8abf-374013f63e45 (old id 7834982)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26303264?dopt=Abstract
- date added to LUP
- 2016-04-01 10:21:25
- date last changed
- 2022-03-19 19:53:04
@article{2f16e633-6699-4bc1-8abf-374013f63e45,
abstract = {{The incretin hormone, glucagon-like peptide 1 (GLP-1), regulates gastric emptying, glucose-dependent stimulation of insulin secretion and glucagon release, and GLP-1 analogs are therefore approved for treatment of type II diabetes. GLP-1 receptors are expressed in reward-related areas such as the ventral tegmental area and nucleus accumbens, and GLP-1 was recently shown to regulate several alcohol-mediated behaviors as well as amphetamine-induced, cocaine-induced and nicotine-induced reward. The present series of experiments were undertaken to investigate the effect of the GLP-1 receptor agonist, liraglutide, on several alcohol-related behaviors in rats that model different aspects of alcohol use disorder in humans. Acute liraglutide treatment suppressed the well-documented effects of alcohol on the mesolimbic dopamine system, namely alcohol-induced accumbal dopamine release and conditioned place preference in mice. In addition, acute administration of liraglutide prevented the alcohol deprivation effect and reduced alcohol intake in outbred rats, while repeated treatment of liraglutide decreased alcohol intake in outbred rats as well as reduced operant self-administration of alcohol in selectively bred Sardinian alcohol-preferring rats. Collectively, these data suggest that GLP-1 receptor agonists could be tested for treatment of alcohol dependence in humans.}},
author = {{Vallöf, Daniel and Maccioni, Paola and Colombo, Giancarlo and Mandrapa, Minja and Jörnulf, Julia Winsa and Egecioglu, Emil and Engel, Jörgen A and Jerlhag, Elisabet}},
issn = {{1369-1600}},
language = {{eng}},
number = {{2}},
pages = {{422--437}},
publisher = {{Wiley-Blackwell}},
series = {{Addiction Biology}},
title = {{The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents.}},
url = {{https://lup.lub.lu.se/search/files/1778778/8611833}},
doi = {{10.1111/adb.12295}},
volume = {{21}},
year = {{2016}},
}