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Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice with Severe Acute Pancreatitis.

Merza, Mohammed LU ; Hartman Magnusson, Hannes LU ; Rahman, Milladur LU ; Hwaiz, Rundk LU ; Zhang, Enming LU ; Renström, Erik LU ; Luo, Lingtao; Mörgelin, Matthias LU ; Regnér, Sara LU and Thorlacius, Henrik LU (2015) In Gastroenterology 149(7). p.1920-1920
Abstract
Neutrophils are involved in development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported contribute to organ dysfunction in patients with infectious diseases. We investigated whether NETs contribute to development of AP in mice.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gastroenterology
volume
149
issue
7
pages
1920 - 1920
publisher
W B Saunders
external identifiers
  • pmid:26302488
  • wos:000365808100044
  • scopus:84952910698
ISSN
1528-0012
DOI
10.1053/j.gastro.2015.08.026
language
English
LU publication?
yes
id
e05eec95-a465-48ac-9908-1648e60de7b4 (old id 7835030)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26302488?dopt=Abstract
date added to LUP
2015-09-07 19:07:52
date last changed
2017-10-22 03:26:21
@article{e05eec95-a465-48ac-9908-1648e60de7b4,
  abstract     = {Neutrophils are involved in development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported contribute to organ dysfunction in patients with infectious diseases. We investigated whether NETs contribute to development of AP in mice.},
  author       = {Merza, Mohammed and Hartman Magnusson, Hannes and Rahman, Milladur and Hwaiz, Rundk and Zhang, Enming and Renström, Erik and Luo, Lingtao and Mörgelin, Matthias and Regnér, Sara and Thorlacius, Henrik},
  issn         = {1528-0012},
  language     = {eng},
  number       = {7},
  pages        = {1920--1920},
  publisher    = {W B Saunders},
  series       = {Gastroenterology},
  title        = {Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice with Severe Acute Pancreatitis.},
  url          = {http://dx.doi.org/10.1053/j.gastro.2015.08.026},
  volume       = {149},
  year         = {2015},
}