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Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.

Renoux, Virginie LU ; Zriwil, Alya LU ; Peitzsch, Claudia; Michaëlsson, Jakob; Friberg, Danielle; Soneji, Shamit LU and Sitnicka Quinn, Ewa LU (2015) In Immunity 43(2). p.394-407
Abstract
Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells... (More)
Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment and provide new insights into the human hematopoietic hierarchy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity
volume
43
issue
2
pages
394 - 407
publisher
Cell Press
external identifiers
  • wos:000360101200020
  • pmid:26287684
  • scopus:84940997861
ISSN
1074-7613
DOI
10.1016/j.immuni.2015.07.011
language
English
LU publication?
yes
id
8aba684a-86e7-470c-874f-9491a6b0585d (old id 7840590)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26287684?dopt=Abstract
date added to LUP
2015-09-06 15:22:33
date last changed
2017-10-29 03:19:15
@article{8aba684a-86e7-470c-874f-9491a6b0585d,
  abstract     = {Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment and provide new insights into the human hematopoietic hierarchy.},
  author       = {Renoux, Virginie and Zriwil, Alya and Peitzsch, Claudia and Michaëlsson, Jakob and Friberg, Danielle and Soneji, Shamit and Sitnicka Quinn, Ewa},
  issn         = {1074-7613},
  language     = {eng},
  number       = {2},
  pages        = {394--407},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.},
  url          = {http://dx.doi.org/10.1016/j.immuni.2015.07.011},
  volume       = {43},
  year         = {2015},
}