Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
(2015) In Immunity 43(2). p.394-407- Abstract
- Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells... (More)
- Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment and provide new insights into the human hematopoietic hierarchy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7840590
- author
- Renoux, Virginie LU ; Zriwil, Alya LU ; Peitzsch, Claudia ; Michaëlsson, Jakob ; Friberg, Danielle ; Soneji, Shamit LU and Sitnicka Quinn, Ewa LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunity
- volume
- 43
- issue
- 2
- pages
- 394 - 407
- publisher
- Cell Press
- external identifiers
-
- wos:000360101200020
- pmid:26287684
- scopus:84940997861
- pmid:26287684
- ISSN
- 1074-7613
- DOI
- 10.1016/j.immuni.2015.07.011
- language
- English
- LU publication?
- yes
- id
- 8aba684a-86e7-470c-874f-9491a6b0585d (old id 7840590)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26287684?dopt=Abstract
- date added to LUP
- 2016-04-01 10:58:03
- date last changed
- 2022-03-27 21:10:48
@article{8aba684a-86e7-470c-874f-9491a6b0585d, abstract = {{Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment and provide new insights into the human hematopoietic hierarchy.}}, author = {{Renoux, Virginie and Zriwil, Alya and Peitzsch, Claudia and Michaëlsson, Jakob and Friberg, Danielle and Soneji, Shamit and Sitnicka Quinn, Ewa}}, issn = {{1074-7613}}, language = {{eng}}, number = {{2}}, pages = {{394--407}}, publisher = {{Cell Press}}, series = {{Immunity}}, title = {{Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.}}, url = {{http://dx.doi.org/10.1016/j.immuni.2015.07.011}}, doi = {{10.1016/j.immuni.2015.07.011}}, volume = {{43}}, year = {{2015}}, }