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Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.

Schüler, Emil; Larsson, Maria; Parris, Toshima Z; Johansson, Martin LU ; Helou, Khalil and Forssell-Aronsson, Eva (2015) In PLoS ONE 10(8).
Abstract
C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
10
issue
8
publisher
Public Library of Science
external identifiers
  • pmid:26287527
  • wos:000360018600122
  • scopus:84942456163
ISSN
1932-6203
DOI
10.1371/journal.pone.0136204
language
English
LU publication?
yes
id
79cb06f6-6b1c-4b8c-a181-ee898eadc213 (old id 7840600)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26287527?dopt=Abstract
date added to LUP
2015-09-06 14:52:50
date last changed
2017-02-05 03:50:03
@article{79cb06f6-6b1c-4b8c-a181-ee898eadc213,
  abstract     = {C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy.},
  articleno    = {e0136204},
  author       = {Schüler, Emil and Larsson, Maria and Parris, Toshima Z and Johansson, Martin and Helou, Khalil and Forssell-Aronsson, Eva},
  issn         = {1932-6203},
  language     = {eng},
  number       = {8},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0136204},
  volume       = {10},
  year         = {2015},
}