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Orthostatic Hypotension: Epidemiology, Prognosis, and Treatment.

Ricci, Fabrizio; De Caterina, Raffaele and Fedorowski, Artur LU (2015) In Journal of the American College of Cardiology 66(7). p.848-860
Abstract
Orthostatic hypotension (OH) is a common cardiovascular disorder, with or without signs of underlying neurodegenerative disease. OH is diagnosed on the basis of an orthostatic challenge and implies a persistent systolic/diastolic blood pressure decrease of at least 20/10 mm Hg upon standing. Its prevalence is age dependent, ranging from 5% in patients <50 years of age to 30% in those >70 years of age. OH may complicate treatment of hypertension, heart failure, and coronary heart disease; cause disabling symptoms, faints, and traumatic injuries; and substantially reduce quality of life. Despite being largely asymptomatic or with minimal symptoms, the presence of OH independently increases mortality and the incidence of myocardial... (More)
Orthostatic hypotension (OH) is a common cardiovascular disorder, with or without signs of underlying neurodegenerative disease. OH is diagnosed on the basis of an orthostatic challenge and implies a persistent systolic/diastolic blood pressure decrease of at least 20/10 mm Hg upon standing. Its prevalence is age dependent, ranging from 5% in patients <50 years of age to 30% in those >70 years of age. OH may complicate treatment of hypertension, heart failure, and coronary heart disease; cause disabling symptoms, faints, and traumatic injuries; and substantially reduce quality of life. Despite being largely asymptomatic or with minimal symptoms, the presence of OH independently increases mortality and the incidence of myocardial infarction, stroke, heart failure, and atrial fibrillation. In this review, we outline the etiology and prevalence of OH in the general population, summarize its relationship with morbidity and mortality, propose a diagnostic and therapeutic algorithm, and delineate current challenges and future perspectives. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of the American College of Cardiology
volume
66
issue
7
pages
848 - 860
publisher
Elsevier USA
external identifiers
  • wos:000359952900012
  • pmid:26271068
  • scopus:84939546831
ISSN
0735-1097
DOI
10.1016/j.jacc.2015.06.1084
language
English
LU publication?
yes
id
786c83bb-c79d-4066-a8b6-5d4924111e6e (old id 7841202)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26271068?dopt=Abstract
date added to LUP
2015-09-05 18:52:21
date last changed
2017-11-05 03:07:21
@article{786c83bb-c79d-4066-a8b6-5d4924111e6e,
  abstract     = {Orthostatic hypotension (OH) is a common cardiovascular disorder, with or without signs of underlying neurodegenerative disease. OH is diagnosed on the basis of an orthostatic challenge and implies a persistent systolic/diastolic blood pressure decrease of at least 20/10 mm Hg upon standing. Its prevalence is age dependent, ranging from 5% in patients &lt;50 years of age to 30% in those &gt;70 years of age. OH may complicate treatment of hypertension, heart failure, and coronary heart disease; cause disabling symptoms, faints, and traumatic injuries; and substantially reduce quality of life. Despite being largely asymptomatic or with minimal symptoms, the presence of OH independently increases mortality and the incidence of myocardial infarction, stroke, heart failure, and atrial fibrillation. In this review, we outline the etiology and prevalence of OH in the general population, summarize its relationship with morbidity and mortality, propose a diagnostic and therapeutic algorithm, and delineate current challenges and future perspectives.},
  author       = {Ricci, Fabrizio and De Caterina, Raffaele and Fedorowski, Artur},
  issn         = {0735-1097},
  language     = {eng},
  number       = {7},
  pages        = {848--860},
  publisher    = {Elsevier USA},
  series       = {Journal of the American College of Cardiology},
  title        = {Orthostatic Hypotension: Epidemiology, Prognosis, and Treatment.},
  url          = {http://dx.doi.org/10.1016/j.jacc.2015.06.1084},
  volume       = {66},
  year         = {2015},
}