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A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources.

Leffler, Jonatan LU ; Ciacma, Katarzyna LU ; Gullstrand, Birgitta LU ; Bengtsson, Anders LU ; Martin, Myriam LU and Blom, Anna LU (2015) In Arthritis Research and Therapy 17.
Abstract
Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since the discovery of neutrophil extracellular traps (NETs), a renewed interest has been sparked in this field of research with multiple studies reporting a decreased ability of patients with SLE to degrade NETs. In this study we extend these findings by investigating the ability of patients with SLE to degrade chromatin from multiple clinically relevant sources.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
17
publisher
BioMed Central
external identifiers
  • pmid:26268365
  • wos:000359340700001
  • scopus:84939178193
ISSN
1478-6362
DOI
10.1186/s13075-015-0726-y
language
English
LU publication?
yes
id
856f0a4e-929f-4761-9bf0-cb3c4a8ea85c (old id 7844085)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26268365?dopt=Abstract
date added to LUP
2015-09-05 18:25:41
date last changed
2017-10-29 03:17:12
@article{856f0a4e-929f-4761-9bf0-cb3c4a8ea85c,
  abstract     = {Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since the discovery of neutrophil extracellular traps (NETs), a renewed interest has been sparked in this field of research with multiple studies reporting a decreased ability of patients with SLE to degrade NETs. In this study we extend these findings by investigating the ability of patients with SLE to degrade chromatin from multiple clinically relevant sources.},
  articleno    = {205},
  author       = {Leffler, Jonatan and Ciacma, Katarzyna and Gullstrand, Birgitta and Bengtsson, Anders and Martin, Myriam and Blom, Anna},
  issn         = {1478-6362},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources.},
  url          = {http://dx.doi.org/10.1186/s13075-015-0726-y},
  volume       = {17},
  year         = {2015},
}