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Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection.

Ohlsson, Bodil LU and Melander, Olle LU (2015) In Drug Target Insights 9. p.21-27
Abstract
Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD were identified. Medical records were scrutinized. Three controls were matched for each patient. Copeptin, midregional fragments of adrenomedullin, pro-atrial natriuretic peptide, and proenkephalin A, as well as N-terminal protachykinin A and proneurotensin were analyzed in the plasma. Sixty-two IBD patients were identified. The only difference... (More)
Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD were identified. Medical records were scrutinized. Three controls were matched for each patient. Copeptin, midregional fragments of adrenomedullin, pro-atrial natriuretic peptide, and proenkephalin A, as well as N-terminal protachykinin A and proneurotensin were analyzed in the plasma. Sixty-two IBD patients were identified. The only difference between patients and controls was higher copeptin levels in the patients compared with controls (P = 0.006), with higher copeptin levels in resected than unresected patients (P = 0.020). There was no difference in any precursor levels between Crohn's disease and ulcerative colitis, between different distributions of disease lesions, or between different treatments. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Target Insights
volume
9
pages
21 - 27
publisher
Libertas Academica
external identifiers
  • pmid:26244009
  • scopus:84938932829
ISSN
1177-3928
DOI
10.4137/DTI.S26589
language
English
LU publication?
yes
id
fe54b368-ee58-4357-9fe4-7d1b3969aaa9 (old id 7844689)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26244009?dopt=Abstract
date added to LUP
2015-09-05 13:17:14
date last changed
2017-01-01 05:41:33
@article{fe54b368-ee58-4357-9fe4-7d1b3969aaa9,
  abstract     = {Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD were identified. Medical records were scrutinized. Three controls were matched for each patient. Copeptin, midregional fragments of adrenomedullin, pro-atrial natriuretic peptide, and proenkephalin A, as well as N-terminal protachykinin A and proneurotensin were analyzed in the plasma. Sixty-two IBD patients were identified. The only difference between patients and controls was higher copeptin levels in the patients compared with controls (P = 0.006), with higher copeptin levels in resected than unresected patients (P = 0.020). There was no difference in any precursor levels between Crohn's disease and ulcerative colitis, between different distributions of disease lesions, or between different treatments.},
  author       = {Ohlsson, Bodil and Melander, Olle},
  issn         = {1177-3928},
  language     = {eng},
  pages        = {21--27},
  publisher    = {Libertas Academica},
  series       = {Drug Target Insights},
  title        = {Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection.},
  url          = {http://dx.doi.org/10.4137/DTI.S26589},
  volume       = {9},
  year         = {2015},
}