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Severe Acute Pancreatitis: Gut Barrier Failure, Systemic Inflammatory Response, Acute Lung Injury, and the Role of the Mesenteric Lymph.

Landahl, Per; Ansari, Daniel LU and Andersson, Roland LU (2015) In Surgical Infections 16(6). p.651-656
Abstract
Severe acute pancreatitis (AP) often leads to distant organ dysfunction with a high morbidity and mortality rate. The most common and earliest organ to fail is the lungs, but the exact pathophysiological mechanisms underlying the disease are still unclear. No successful targeted therapy exists, and treatment is limited to organ supportive care. It is believed that the gut is involved in the development of distant organ failure, as severe AP is associated with changes in the microcirculation, gut permeability/motility, bacterial translocation, and activation of the gut-associated lymphoid tissue (GALT). Experimental evidence implicates the mesenteric lymph as a primary route for these toxic factors to gain access to the systemic... (More)
Severe acute pancreatitis (AP) often leads to distant organ dysfunction with a high morbidity and mortality rate. The most common and earliest organ to fail is the lungs, but the exact pathophysiological mechanisms underlying the disease are still unclear. No successful targeted therapy exists, and treatment is limited to organ supportive care. It is believed that the gut is involved in the development of distant organ failure, as severe AP is associated with changes in the microcirculation, gut permeability/motility, bacterial translocation, and activation of the gut-associated lymphoid tissue (GALT). Experimental evidence implicates the mesenteric lymph as a primary route for these toxic factors to gain access to the systemic circulation. This literature overview was made to survey these mechanisms and the potential of surgical interventions on the thoracic duct as a means of therapy. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Surgical Infections
volume
16
issue
6
pages
651 - 656
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:26237406
  • wos:000365530800001
  • scopus:84948649579
ISSN
1557-8674
DOI
10.1089/sur.2015.034
language
English
LU publication?
yes
id
928e0dd8-8f12-43e2-8e3f-5573b88ee2ee (old id 7844940)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26237406?dopt=Abstract
date added to LUP
2015-09-05 12:12:39
date last changed
2017-11-05 03:26:58
@article{928e0dd8-8f12-43e2-8e3f-5573b88ee2ee,
  abstract     = {Severe acute pancreatitis (AP) often leads to distant organ dysfunction with a high morbidity and mortality rate. The most common and earliest organ to fail is the lungs, but the exact pathophysiological mechanisms underlying the disease are still unclear. No successful targeted therapy exists, and treatment is limited to organ supportive care. It is believed that the gut is involved in the development of distant organ failure, as severe AP is associated with changes in the microcirculation, gut permeability/motility, bacterial translocation, and activation of the gut-associated lymphoid tissue (GALT). Experimental evidence implicates the mesenteric lymph as a primary route for these toxic factors to gain access to the systemic circulation. This literature overview was made to survey these mechanisms and the potential of surgical interventions on the thoracic duct as a means of therapy.},
  author       = {Landahl, Per and Ansari, Daniel and Andersson, Roland},
  issn         = {1557-8674},
  language     = {eng},
  number       = {6},
  pages        = {651--656},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Surgical Infections},
  title        = {Severe Acute Pancreatitis: Gut Barrier Failure, Systemic Inflammatory Response, Acute Lung Injury, and the Role of the Mesenteric Lymph.},
  url          = {http://dx.doi.org/10.1089/sur.2015.034},
  volume       = {16},
  year         = {2015},
}