Intervention thresholds for osteoporosis in the UK
(2005) In Bone 36(1). p.22-32- Abstract
- The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in women based on data from the UK. We modelled the effects of an intervention costing pound350 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect (offset time) for a further 5 years. Sensitivity analyses included a range of treatment duration (3-10 years), intervention costs (pound300-400/year) and offset times (0-15 years). Data on costs and risks were from the UK. Costs included direct costs, but excluded indirect costs due to morbidity. A threshold for cost-effectiveness of pound30,000/QALY gained was used. With the base case (pound350 per year; 35%... (More)
- The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in women based on data from the UK. We modelled the effects of an intervention costing pound350 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect (offset time) for a further 5 years. Sensitivity analyses included a range of treatment duration (3-10 years), intervention costs (pound300-400/year) and offset times (0-15 years). Data on costs and risks were from the UK. Costs included direct costs, but excluded indirect costs due to morbidity. A threshold for cost-effectiveness of pound30,000/QALY gained was used. With the base case (pound350 per year; 35% efficacy) treatment in women was cost-effective with a 10-year hip fracture probability that ranged from 1.1% at the age of 50 years to 9.0% at the age of 85 years. Intervention thresholds were sensitive to the assumed costs and offset time. The exclusion of osteoporotic fractures other than hip fracture significantly increased the cost-effectiveness ratio because of the substantial morbidity from such other fractures, particularly at younger ages. Cost-effective scenarios were found for women at the threshold for osteoporosis from the age of 60 years. Treatment of established osteoporosis was cost-effective irrespective of age. We conclude that the inclusion of all osteoporotic fractures has a marked effect on intervention thresholds, that these vary with age and that available treatments can be targeted cost-effectively to individuals from the UK at moderately increased fracture risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/897531
- author
- Kanis, JA ; Borgsrom, F ; Zethraeus, N ; Johnell, Olof LU ; Oden, A and Jonsson, B
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- threshold, intervention, cost-effectiveness, hip fracture, osteoporotic fracture
- in
- Bone
- volume
- 36
- issue
- 1
- pages
- 22 - 32
- publisher
- Elsevier
- external identifiers
-
- pmid:15663999
- wos:000226733500004
- scopus:12344310388
- pmid:15663999
- ISSN
- 1873-2763
- DOI
- 10.1016/j.bone.2004.08.018
- language
- English
- LU publication?
- yes
- id
- 784e955b-4695-476c-ac18-782ffc8d44b8 (old id 897531)
- date added to LUP
- 2016-04-01 16:52:12
- date last changed
- 2024-05-10 12:29:40
@article{784e955b-4695-476c-ac18-782ffc8d44b8, abstract = {{The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in women based on data from the UK. We modelled the effects of an intervention costing pound350 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect (offset time) for a further 5 years. Sensitivity analyses included a range of treatment duration (3-10 years), intervention costs (pound300-400/year) and offset times (0-15 years). Data on costs and risks were from the UK. Costs included direct costs, but excluded indirect costs due to morbidity. A threshold for cost-effectiveness of pound30,000/QALY gained was used. With the base case (pound350 per year; 35% efficacy) treatment in women was cost-effective with a 10-year hip fracture probability that ranged from 1.1% at the age of 50 years to 9.0% at the age of 85 years. Intervention thresholds were sensitive to the assumed costs and offset time. The exclusion of osteoporotic fractures other than hip fracture significantly increased the cost-effectiveness ratio because of the substantial morbidity from such other fractures, particularly at younger ages. Cost-effective scenarios were found for women at the threshold for osteoporosis from the age of 60 years. Treatment of established osteoporosis was cost-effective irrespective of age. We conclude that the inclusion of all osteoporotic fractures has a marked effect on intervention thresholds, that these vary with age and that available treatments can be targeted cost-effectively to individuals from the UK at moderately increased fracture risk.}}, author = {{Kanis, JA and Borgsrom, F and Zethraeus, N and Johnell, Olof and Oden, A and Jonsson, B}}, issn = {{1873-2763}}, keywords = {{threshold; intervention; cost-effectiveness; hip fracture; osteoporotic fracture}}, language = {{eng}}, number = {{1}}, pages = {{22--32}}, publisher = {{Elsevier}}, series = {{Bone}}, title = {{Intervention thresholds for osteoporosis in the UK}}, url = {{http://dx.doi.org/10.1016/j.bone.2004.08.018}}, doi = {{10.1016/j.bone.2004.08.018}}, volume = {{36}}, year = {{2005}}, }