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The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis.

Kherad, Mehrsa LU ; Mellström, D; Rosengren, Björn LU ; Hasserius, Ralph LU ; Nilsson, Jan-Åke LU ; Redlund-Johnell, Inga LU ; Ohlsson, C; Lorentzon, M and Karlsson, Magnus K LU (2015) In The Bone & Joint Journal 97B(8). p.1106-1110
Abstract
We sought to determine whether specific characteristics of vertebral fractures in elderly men are associated with low bone mineral density (BMD) and osteoporosis. Mister osteoporosis Sweden is a population based cohort study involving 3014 men aged 69 to 81 years. Of these, 1427 had readable lateral radiographs of the thoracic and lumbar spine. Total body (TB) BMD (g/cm²) and total right hip (TH) BMD were measured by dual energy x-ray absorptiometry. The proportion of men with osteoporosis was calculated from TH BMD. There were 215 men (15.1%) with a vertebral fracture. Those with a fracture had lower TB BMD than those without (p < 0.001). Among men with a fracture, TB BMD was lower in those with more than three fractures (p = 0.02),... (More)
We sought to determine whether specific characteristics of vertebral fractures in elderly men are associated with low bone mineral density (BMD) and osteoporosis. Mister osteoporosis Sweden is a population based cohort study involving 3014 men aged 69 to 81 years. Of these, 1427 had readable lateral radiographs of the thoracic and lumbar spine. Total body (TB) BMD (g/cm²) and total right hip (TH) BMD were measured by dual energy x-ray absorptiometry. The proportion of men with osteoporosis was calculated from TH BMD. There were 215 men (15.1%) with a vertebral fracture. Those with a fracture had lower TB BMD than those without (p < 0.001). Among men with a fracture, TB BMD was lower in those with more than three fractures (p = 0.02), those with biconcave fractures (p = 0.02) and those with vertebral body compression of > 42% (worst quartile) (p = 0.03). The mean odds ratio (OR) for having osteoporosis when having any type of vertebral fracture was 6.1 (95% confidence interval (CI) 3.9 to 9.5) compared with those without a fracture. A combination of more than three fractures and compression in the worst quartile had a mean OR of 114.2 (95% CI 6.7 to 1938.3) of having osteoporosis compared with those without a fracture. We recommend BMD studies to be undertaken in these subcohorts of elderly men with a vertebral fracture. Cite this article: 2015;97-B:1106-10. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Bone & Joint Journal
volume
97B
issue
8
pages
1106 - 1110
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • pmid:26224829
  • wos:000359093100017
  • scopus:84938364335
ISSN
2049-4408
DOI
10.1302/0301-620X.97B8.35032
language
English
LU publication?
yes
id
c71128f0-896f-4842-a939-26c1950523e1 (old id 7850906)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26224829?dopt=Abstract
date added to LUP
2015-09-02 14:39:41
date last changed
2017-06-18 03:25:32
@article{c71128f0-896f-4842-a939-26c1950523e1,
  abstract     = {We sought to determine whether specific characteristics of vertebral fractures in elderly men are associated with low bone mineral density (BMD) and osteoporosis. Mister osteoporosis Sweden is a population based cohort study involving 3014 men aged 69 to 81 years. Of these, 1427 had readable lateral radiographs of the thoracic and lumbar spine. Total body (TB) BMD (g/cm²) and total right hip (TH) BMD were measured by dual energy x-ray absorptiometry. The proportion of men with osteoporosis was calculated from TH BMD. There were 215 men (15.1%) with a vertebral fracture. Those with a fracture had lower TB BMD than those without (p &lt; 0.001). Among men with a fracture, TB BMD was lower in those with more than three fractures (p = 0.02), those with biconcave fractures (p = 0.02) and those with vertebral body compression of &gt; 42% (worst quartile) (p = 0.03). The mean odds ratio (OR) for having osteoporosis when having any type of vertebral fracture was 6.1 (95% confidence interval (CI) 3.9 to 9.5) compared with those without a fracture. A combination of more than three fractures and compression in the worst quartile had a mean OR of 114.2 (95% CI 6.7 to 1938.3) of having osteoporosis compared with those without a fracture. We recommend BMD studies to be undertaken in these subcohorts of elderly men with a vertebral fracture. Cite this article: 2015;97-B:1106-10.},
  author       = {Kherad, Mehrsa and Mellström, D and Rosengren, Björn and Hasserius, Ralph and Nilsson, Jan-Åke and Redlund-Johnell, Inga and Ohlsson, C and Lorentzon, M and Karlsson, Magnus K},
  issn         = {2049-4408},
  language     = {eng},
  number       = {8},
  pages        = {1106--1110},
  publisher    = {British Editorial Society of Bone & Joint Surgery},
  series       = {The Bone & Joint Journal},
  title        = {The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis.},
  url          = {http://dx.doi.org/10.1302/0301-620X.97B8.35032},
  volume       = {97B},
  year         = {2015},
}