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Non protein bound iron concentrations in amniotic fluid

Gazzolo, D; Perrone, S; Paffetti, P; Longini, M; Vezzosi, P; Bruschettini, Matteo LU ; Lituania, M and Buonocore, G (2005) In Clinical Biochemistry 38(7). p.674-677
Abstract
Objectives: To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. Design and methods: Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation. Results: NPBI increased progressively from weeks 14-15 to weeks 15-16, peaking at 17-18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically... (More)
Objectives: To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. Design and methods: Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation. Results: NPBI increased progressively from weeks 14-15 to weeks 15-16, peaking at 17-18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically significant regression coefficient with GA, bi-parietal diameter and transverse cerebellar diameter. Conclusions: The present data constitutes the first quantification of NPBI concentrations in amniotic fluid under physiological conditions. Correlations with GA and ultrasound fetal biometry suggest that NPBI may play a role in fetal growth. (C) 2005 The Canadian Society of Clinical Chemists. All rights reserved. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
stress, oxidative, pregnancy, ammotic fluid, fetus, non protein bound iron
in
Clinical Biochemistry
volume
38
issue
7
pages
674 - 677
publisher
Elsevier
external identifiers
  • wos:000230697100012
  • scopus:21844441618
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2005.03.010
language
English
LU publication?
no
id
d0d42f52-feb7-4b38-b94a-3cf38f22a5b2 (old id 7856268)
date added to LUP
2015-09-07 11:32:15
date last changed
2017-01-08 04:13:30
@article{d0d42f52-feb7-4b38-b94a-3cf38f22a5b2,
  abstract     = {Objectives: To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. Design and methods: Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation. Results: NPBI increased progressively from weeks 14-15 to weeks 15-16, peaking at 17-18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically significant regression coefficient with GA, bi-parietal diameter and transverse cerebellar diameter. Conclusions: The present data constitutes the first quantification of NPBI concentrations in amniotic fluid under physiological conditions. Correlations with GA and ultrasound fetal biometry suggest that NPBI may play a role in fetal growth. (C) 2005 The Canadian Society of Clinical Chemists. All rights reserved.},
  author       = {Gazzolo, D and Perrone, S and Paffetti, P and Longini, M and Vezzosi, P and Bruschettini, Matteo and Lituania, M and Buonocore, G},
  issn         = {1873-2933},
  keyword      = {stress,oxidative,pregnancy,ammotic fluid,fetus,non protein bound iron},
  language     = {eng},
  number       = {7},
  pages        = {674--677},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {Non protein bound iron concentrations in amniotic fluid},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2005.03.010},
  volume       = {38},
  year         = {2005},
}