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Campylobacter infections with and without bacteraemia- a comparative retrospective population-based study

Sunnerhagen, Torgny LU orcid ; Grenthe, Rasmus ; Kampmann, Christian LU ; Karlsson Söbirk, Sara LU orcid and Bläckberg, Anna LU (2024) In Open Forum Infectious Diseases 11(3).
Abstract
Background
Bacteraemia with species in the genus Campylobacter is rare, and knowledge of the disease course in comparison to Campylobacter enteritis is limited.
Methods
This is a retrospective population-based study. Episodes of Campylobacter bacteraemia, and Campylobacter enteritis with a concurrent negative blood culture, that occurred between 2015 and 2022 in southern Sweden were identified through the laboratory database. Medical records were reviewed and clinical features between patients with bacteraemic Campylobacter infections were compared with patients with Campylobacter spp. found in faeces.
Results
A total of 29 bacteraemic infections with Campylobacter and 119 patients with Campylobacter spp. found in... (More)
Background
Bacteraemia with species in the genus Campylobacter is rare, and knowledge of the disease course in comparison to Campylobacter enteritis is limited.
Methods
This is a retrospective population-based study. Episodes of Campylobacter bacteraemia, and Campylobacter enteritis with a concurrent negative blood culture, that occurred between 2015 and 2022 in southern Sweden were identified through the laboratory database. Medical records were reviewed and clinical features between patients with bacteraemic Campylobacter infections were compared with patients with Campylobacter spp. found in faeces.
Results
A total of 29 bacteraemic infections with Campylobacter and 119 patients with Campylobacter spp. found in faeces were included. Patients with Campylobacter bacteraemia were statistically significantly older compared to patients with only enteritis (72 years, IQR 58-62 years, and 58 years, IQR 33-67 years, respectively, p < 0.0001). Eleven patients with bacteraemia developed sepsis within 48 hours from blood culturing and no patient died within 30 days from hospital admission.
Conclusions
Campylobacter bacteraemia is rare and occurs mainly in the elderly with co-morbidities. In comparison to Campylobacter infections limited to the gastrointestinal tract, patients with bacteraemic Campylobacter infections are older and seem more prone to develop sepsis. Classical gastroenteritis symptoms in bacteraemic patients with Campylobacter may be absent. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bacteremia, Campylobacter, enteritis, outcome
in
Open Forum Infectious Diseases
volume
11
issue
3
article number
ofae131
pages
6 pages
publisher
Oxford University Press
external identifiers
  • scopus:85189164901
ISSN
2328-8957
DOI
10.1093/ofid/ofae131
project
Invasive infections with gastrointestinal pathogens
language
English
LU publication?
yes
id
785be04c-4e6e-47b1-936b-7c70a65aad93
date added to LUP
2024-03-13 17:03:43
date last changed
2024-04-18 09:29:48
@article{785be04c-4e6e-47b1-936b-7c70a65aad93,
  abstract     = {{Background<br/>Bacteraemia with species in the genus Campylobacter is rare, and knowledge of the disease course in comparison to Campylobacter enteritis is limited.<br/>Methods<br/>This is a retrospective population-based study. Episodes of Campylobacter bacteraemia, and Campylobacter enteritis with a concurrent negative blood culture, that occurred between 2015 and 2022 in southern Sweden were identified through the laboratory database. Medical records were reviewed and clinical features between patients with bacteraemic Campylobacter infections were compared with patients with Campylobacter spp. found in faeces.<br/>Results<br/>A total of 29 bacteraemic infections with Campylobacter and 119 patients with Campylobacter spp. found in faeces were included. Patients with Campylobacter bacteraemia were statistically significantly older compared to patients with only enteritis (72 years, IQR 58-62 years, and 58 years, IQR 33-67 years, respectively, p &lt; 0.0001). Eleven patients with bacteraemia developed sepsis within 48 hours from blood culturing and no patient died within 30 days from hospital admission.<br/>Conclusions<br/>Campylobacter bacteraemia is rare and occurs mainly in the elderly with co-morbidities. In comparison to Campylobacter infections limited to the gastrointestinal tract, patients with bacteraemic Campylobacter infections are older and seem more prone to develop sepsis. Classical gastroenteritis symptoms in bacteraemic patients with Campylobacter may be absent.}},
  author       = {{Sunnerhagen, Torgny and Grenthe, Rasmus and Kampmann, Christian and Karlsson Söbirk, Sara and Bläckberg, Anna}},
  issn         = {{2328-8957}},
  keywords     = {{bacteremia; Campylobacter; enteritis; outcome}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  publisher    = {{Oxford University Press}},
  series       = {{Open Forum Infectious Diseases}},
  title        = {{Campylobacter infections with and without bacteraemia- a comparative retrospective population-based study}},
  url          = {{https://lup.lub.lu.se/search/files/178048746/ofae131.pdf}},
  doi          = {{10.1093/ofid/ofae131}},
  volume       = {{11}},
  year         = {{2024}},
}