Advanced

Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy

Ljungberg, Michael LU and Sjögreen Gleisner, Katarina LU (2015) In Diagnostics 5(3). p.296-317
Abstract
Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the... (More)
Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dosimetry, Monte Carlo, SPECT, hybrid, CT, absorbed dose, therapy, reconstruction, quantitation, activity
in
Diagnostics
volume
5
issue
3
pages
296 - 317
publisher
MDPI AG
external identifiers
  • wos:000362546900004
  • pmid:26854156
ISSN
2075-4418
DOI
10.3390/diagnostics5030296
language
English
LU publication?
yes
id
62a401ac-cb5a-449b-859e-0222c00a13e5 (old id 7865611)
date added to LUP
2015-09-14 09:08:02
date last changed
2016-12-20 03:18:54
@article{62a401ac-cb5a-449b-859e-0222c00a13e5,
  abstract     = {Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions.},
  author       = {Ljungberg, Michael and Sjögreen Gleisner, Katarina},
  issn         = {2075-4418},
  keyword      = {dosimetry,Monte Carlo,SPECT,hybrid,CT,absorbed dose,therapy,reconstruction,quantitation,activity},
  language     = {eng},
  number       = {3},
  pages        = {296--317},
  publisher    = {MDPI AG},
  series       = {Diagnostics},
  title        = {Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy},
  url          = {http://dx.doi.org/10.3390/diagnostics5030296},
  volume       = {5},
  year         = {2015},
}