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An altered immune response to Epstein-Barr virus in multiple sclerosis - A prospective study

Sundstrom, P ; Juto, P ; Wadell, G ; Hallmans, G ; Svenningsson, A ; Nystrom, L ; Dillner, Joakim LU and Forsgren, L (2004) In Neurology 62(12). p.2277-2282
Abstract
Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy... (More)
Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurology
volume
62
issue
12
pages
2277 - 2282
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000222178600023
  • pmid:15210894
  • scopus:2942752168
ISSN
1526-632X
language
English
LU publication?
yes
id
78b9cd75-fd1d-4664-933f-c7cab6879d5b (old id 273747)
alternative location
http://www.neurology.org/cgi/content/abstract/62/12/2277
date added to LUP
2016-04-01 15:53:02
date last changed
2022-04-07 01:23:06
@article{78b9cd75-fd1d-4664-933f-c7cab6879d5b,
  abstract     = {{Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.}},
  author       = {{Sundstrom, P and Juto, P and Wadell, G and Hallmans, G and Svenningsson, A and Nystrom, L and Dillner, Joakim and Forsgren, L}},
  issn         = {{1526-632X}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2277--2282}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Neurology}},
  title        = {{An altered immune response to Epstein-Barr virus in multiple sclerosis - A prospective study}},
  url          = {{http://www.neurology.org/cgi/content/abstract/62/12/2277}},
  volume       = {{62}},
  year         = {{2004}},
}