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Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells

Békássy, Albert LU ; Liliemark, Jan ; Garwicz, Stanislaw LU ; Wiebe, Thomas LU ; Gulliksson, Hans and Peterson, Curt (1990) In Medical and Pediatric Oncology 18(2). p.136-142
Abstract
Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration... (More)
Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration of hydrocortison and ara-C. Hydrocortison did not increase ara-CTP retention in the leukemic cells, nor did it effect CSF pleocytosis. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intrathecal, intraventricular, child, acute leukemia, CNS Leukemia
in
Medical and Pediatric Oncology
volume
18
issue
2
pages
136 - 142
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:2304422
  • scopus:0025219695
ISSN
1096-911X
DOI
10.1002/mpo.2950180210
language
English
LU publication?
yes
id
78e36588-7a70-4381-83c3-724942f946a5 (old id 1104976)
date added to LUP
2016-04-01 11:42:24
date last changed
2021-01-03 05:08:30
@article{78e36588-7a70-4381-83c3-724942f946a5,
  abstract     = {{Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration of hydrocortison and ara-C. Hydrocortison did not increase ara-CTP retention in the leukemic cells, nor did it effect CSF pleocytosis.}},
  author       = {{Békássy, Albert and Liliemark, Jan and Garwicz, Stanislaw and Wiebe, Thomas and Gulliksson, Hans and Peterson, Curt}},
  issn         = {{1096-911X}},
  keywords     = {{intrathecal; intraventricular; child; acute leukemia; CNS Leukemia}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{136--142}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Medical and Pediatric Oncology}},
  title        = {{Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells}},
  url          = {{http://dx.doi.org/10.1002/mpo.2950180210}},
  doi          = {{10.1002/mpo.2950180210}},
  volume       = {{18}},
  year         = {{1990}},
}