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RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6

Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. LU ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Kromidas, L. and La Cava, S. , et al. (2016) In Food and Chemical Toxicology 97. p.168-179
Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog linalool (CAS # 78-70-6) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the local respiratory endpoint. The repeated dose, developmental and reproductive toxicity endpoints were completed using nerolidol (isomer unspecified, CAS # 7212-44-4) as a suitable read across analog, which provided a MOE > 100. The... (More)

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog linalool (CAS # 78-70-6) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the local respiratory endpoint. The repeated dose, developmental and reproductive toxicity endpoints were completed using nerolidol (isomer unspecified, CAS # 7212-44-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergencity, Repeated dose, Skin sensitization
in
Food and Chemical Toxicology
volume
97
pages
168 - 179
publisher
Elsevier
external identifiers
  • scopus:84997199479
  • pmid:27663839
ISSN
0278-6915
DOI
10.1016/j.fct.2016.09.024
language
English
LU publication?
no
id
78fc2a41-d884-48ca-b0fa-4910efbf61c0
date added to LUP
2016-12-12 11:58:52
date last changed
2024-03-07 18:23:14
@article{78fc2a41-d884-48ca-b0fa-4910efbf61c0,
  abstract     = {{<p>The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog linalool (CAS # 78-70-6) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE &gt; 100 for the local respiratory endpoint. The repeated dose, developmental and reproductive toxicity endpoints were completed using nerolidol (isomer unspecified, CAS # 7212-44-4) as a suitable read across analog, which provided a MOE &gt; 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.</p>}},
  author       = {{Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Miyachi, Y. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.}},
  issn         = {{0278-6915}},
  keywords     = {{Developmental and reproductive toxicity; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergencity; Repeated dose; Skin sensitization}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{168--179}},
  publisher    = {{Elsevier}},
  series       = {{Food and Chemical Toxicology}},
  title        = {{RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2016.09.024}},
  doi          = {{10.1016/j.fct.2016.09.024}},
  volume       = {{97}},
  year         = {{2016}},
}