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Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk

Li, Y. ; Melander, O. LU orcid ; Brunnström, H. LU orcid and Amos, C.I. (2022) In Human Molecular Genetics 31(16). p.2831-2843
Abstract
Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency
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author
; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
case control study, female, genetic predisposition, genetics, genome-wide association study, human, lung, lung tumor, male, single nucleotide polymorphism, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lung, Lung Neoplasms, Male, Polymorphism, Single Nucleotide
in
Human Molecular Genetics
volume
31
issue
16
pages
13 pages
publisher
Oxford University Press
external identifiers
  • scopus:85137124752
  • pmid:35138370
ISSN
1460-2083
DOI
10.1093/hmg/ddac030
language
English
LU publication?
yes
id
7919beac-6557-451e-8669-bd9f2f0ea8f5
date added to LUP
2022-12-19 11:51:55
date last changed
2024-01-18 16:37:34
@article{7919beac-6557-451e-8669-bd9f2f0ea8f5,
  abstract     = {{Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency}},
  author       = {{Li, Y. and Melander, O. and Brunnström, H. and Amos, C.I.}},
  issn         = {{1460-2083}},
  keywords     = {{case control study; female; genetic predisposition; genetics; genome-wide association study; human; lung; lung tumor; male; single nucleotide polymorphism; Case-Control Studies; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Lung; Lung Neoplasms; Male; Polymorphism, Single Nucleotide}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{16}},
  pages        = {{2831--2843}},
  publisher    = {{Oxford University Press}},
  series       = {{Human Molecular Genetics}},
  title        = {{Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk}},
  url          = {{http://dx.doi.org/10.1093/hmg/ddac030}},
  doi          = {{10.1093/hmg/ddac030}},
  volume       = {{31}},
  year         = {{2022}},
}