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Epigenetic markers to further understand insulin resistance

Ling, Charlotte LU and Rönn, Tina LU (2016) In Diabetologia 59(11). p.2295-2297
Abstract

Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its related risk factors including age and obesity. Insulin resistance, a key risk factor for type 2 diabetes, may also be associated with altered DNA methylation in visceral and subcutaneous adipose tissue. Furthermore, linking epigenetic variation in target tissues to similar changes in blood cells may identify new blood-based biomarkers. In this issue of Diabetologia, Arner et al studied the transcriptome and methylome in subcutaneous and visceral adipose tissue of 80 obese women who were either insulin-sensitive or -resistant (DOI 10.1007/s00125-016-4074-5). While they found differences in gene expression between the two groups, no alterations in DNA... (More)

Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its related risk factors including age and obesity. Insulin resistance, a key risk factor for type 2 diabetes, may also be associated with altered DNA methylation in visceral and subcutaneous adipose tissue. Furthermore, linking epigenetic variation in target tissues to similar changes in blood cells may identify new blood-based biomarkers. In this issue of Diabetologia, Arner et al studied the transcriptome and methylome in subcutaneous and visceral adipose tissue of 80 obese women who were either insulin-sensitive or -resistant (DOI 10.1007/s00125-016-4074-5). While they found differences in gene expression between the two groups, no alterations in DNA methylation were found after correction for multiple testing. Nevertheless, based on nominal p values, their methylation data overlapped with methylation differences identified in adipose tissue of individuals with type 2 diabetes compared with healthy individuals. Differential methylation of these overlapping CpG sites may predispose to diabetes by occurring already in the insulin-resistant state. Furthermore, some methylation changes may contribute to an inflammatory process in adipose tissue since the identified CpG sites were annotated to genes encoding proteins involved in inflammation. Finally, the methylation pattern in circulating leucocytes did not mirror the adipose tissue methylome of these 80 women. Together, identifying novel molecular mechanisms contributing to insulin resistance and type 2 diabetes may help advance the search for new therapeutic alternatives.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipose tissue, Biomarker, DNA methylation, Epigenetics, EWAS, Insulin resistance, Subcutaneous, Type 2 diabetes, Visceral
in
Diabetologia
volume
59
issue
11
pages
2295 - 2297
publisher
Springer Verlag
external identifiers
  • scopus:84988569360
  • wos:000387596100004
ISSN
0012-186X
DOI
10.1007/s00125-016-4109-y
language
English
LU publication?
yes
id
7923ebd4-c217-4ee2-aff7-00a3a431af56
date added to LUP
2016-10-13 09:22:06
date last changed
2017-04-09 04:50:31
@misc{7923ebd4-c217-4ee2-aff7-00a3a431af56,
  abstract     = {<p>Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its related risk factors including age and obesity. Insulin resistance, a key risk factor for type 2 diabetes, may also be associated with altered DNA methylation in visceral and subcutaneous adipose tissue. Furthermore, linking epigenetic variation in target tissues to similar changes in blood cells may identify new blood-based biomarkers. In this issue of Diabetologia, Arner et al studied the transcriptome and methylome in subcutaneous and visceral adipose tissue of 80 obese women who were either insulin-sensitive or -resistant (DOI 10.1007/s00125-016-4074-5). While they found differences in gene expression between the two groups, no alterations in DNA methylation were found after correction for multiple testing. Nevertheless, based on nominal p values, their methylation data overlapped with methylation differences identified in adipose tissue of individuals with type 2 diabetes compared with healthy individuals. Differential methylation of these overlapping CpG sites may predispose to diabetes by occurring already in the insulin-resistant state. Furthermore, some methylation changes may contribute to an inflammatory process in adipose tissue since the identified CpG sites were annotated to genes encoding proteins involved in inflammation. Finally, the methylation pattern in circulating leucocytes did not mirror the adipose tissue methylome of these 80 women. Together, identifying novel molecular mechanisms contributing to insulin resistance and type 2 diabetes may help advance the search for new therapeutic alternatives.</p>},
  author       = {Ling, Charlotte and Rönn, Tina},
  issn         = {0012-186X},
  keyword      = {Adipose tissue,Biomarker,DNA methylation,Epigenetics,EWAS,Insulin resistance,Subcutaneous,Type 2 diabetes,Visceral},
  language     = {eng},
  month        = {11},
  number       = {11},
  pages        = {2295--2297},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Epigenetic markers to further understand insulin resistance},
  url          = {http://dx.doi.org/10.1007/s00125-016-4109-y},
  volume       = {59},
  year         = {2016},
}