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Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)

Wozniak, Magdalena B.; Brennan, Paul; Brenner, Darren R.; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Fagherazzi, Guy and Katzke, Verena, et al. (2015) In International Journal of Cancer 137(8). p.1953-1966
Abstract
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n=931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at... (More)
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n=931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), 0.91 (0.63-1.30), respectively, (p(trend)=0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer. What's new? Previous studies have indicated that environmental or lifestyle factors may be involved in the etiology of renal cancer, and that moderate alcohol consumption may reduce the risk of this type of cancer. In this very large European study (nearly 500,000 subjects), the authors found that, indeed, total alcohol consumption was inversely associated with renal cancer overall (for all subsites combined), and also with cancers of the renal parenchyma. (Less)
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keywords
cohort study, EPIC, alcohol consumption, risk factors, renal cell carcinoma, kidney cancer
in
International Journal of Cancer
volume
137
issue
8
pages
1953 - 1966
publisher
John Wiley & Sons
external identifiers
  • wos:000359350600023
  • scopus:84938984278
ISSN
0020-7136
DOI
10.1002/ijc.29559
language
English
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yes
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71e8d160-7920-468f-8d93-db22cc5bfef7 (old id 7972476)
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2015-10-01 07:36:19
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@article{71e8d160-7920-468f-8d93-db22cc5bfef7,
  abstract     = {Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n=931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), 0.91 (0.63-1.30), respectively, (p(trend)=0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer. What's new? Previous studies have indicated that environmental or lifestyle factors may be involved in the etiology of renal cancer, and that moderate alcohol consumption may reduce the risk of this type of cancer. In this very large European study (nearly 500,000 subjects), the authors found that, indeed, total alcohol consumption was inversely associated with renal cancer overall (for all subsites combined), and also with cancers of the renal parenchyma.},
  author       = {Wozniak, Magdalena B. and Brennan, Paul and Brenner, Darren R. and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Fagherazzi, Guy and Katzke, Verena and Kuehn, Tilman and Boeing, Heiner and Bergmann, Manuela M. and Steffen, Annika and Naska, Androniki and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Saieva, Calogero and Grioni, Sara and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and Bueno-de-Mesquita, H. B(as) and Peeters, Petra H. and Hjartaker, Anette and Weiderpass, Elisabete and Arriola, Larraitz and Molina-Montes, Esther and Duell, Eric J. and Santiuste, Carmen and Alonso de la Torre, Ramon and Barricarte Gurrea, Aurelio and Stocks, Tanja and Johansson, Mattias and Ljungberg, Borje and Wareham, Nick and Khaw, Kay-Tee and Travis, Ruth C. and Cross, Amanda J. and Murphy, Neil and Riboli, Elio and Scelo, Ghislaine},
  issn         = {0020-7136},
  keyword      = {cohort study,EPIC,alcohol consumption,risk factors,renal cell carcinoma,kidney cancer},
  language     = {eng},
  number       = {8},
  pages        = {1953--1966},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1002/ijc.29559},
  volume       = {137},
  year         = {2015},
}