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Natural Pseudoguaianolides Prepared from Damsin

Villagomez, Rodrigo LU ; Quiroz, M.; Tito, A.; Sterner, Olov LU and Almanza, G. R. (2015) In Chemistry of Natural Compounds 51(4). p.675-680
Abstract
Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3 alpha-hydroxydamsin (4), 3 alpha-acetoxydamsin (5), and 11 beta,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sesquiterpene lactones, pseudoguaianolides, semi-synthesis, ambrosanolides, derivatization, damsin
in
Chemistry of Natural Compounds
volume
51
issue
4
pages
675 - 680
publisher
Springer
external identifiers
  • wos:000359431500016
  • scopus:84938991384
ISSN
0009-3130
DOI
10.1007/s10600-015-1382-9
language
English
LU publication?
yes
id
e0f5b6ab-f9a6-4199-ad11-6f9250e978ec (old id 7975528)
date added to LUP
2015-09-24 14:52:27
date last changed
2017-10-08 03:14:26
@article{e0f5b6ab-f9a6-4199-ad11-6f9250e978ec,
  abstract     = {Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3 alpha-hydroxydamsin (4), 3 alpha-acetoxydamsin (5), and 11 beta,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.},
  author       = {Villagomez, Rodrigo and Quiroz, M. and Tito, A. and Sterner, Olov and Almanza, G. R.},
  issn         = {0009-3130},
  keyword      = {sesquiterpene lactones,pseudoguaianolides,semi-synthesis,ambrosanolides,derivatization,damsin},
  language     = {eng},
  number       = {4},
  pages        = {675--680},
  publisher    = {Springer},
  series       = {Chemistry of Natural Compounds},
  title        = {Natural Pseudoguaianolides Prepared from Damsin},
  url          = {http://dx.doi.org/10.1007/s10600-015-1382-9},
  volume       = {51},
  year         = {2015},
}