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Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

Aqueveque, Pedro; Leonardo Cespedes, Carlos; Becerra, Jose; Davila, Marcelo and Sterner, Olov LU (2015) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 70(3-4). p.97-102
Abstract
Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2... (More)
Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibacterial activity, MIC, MS-3, Stereum rameale, vibralactone
in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
70
issue
3-4
pages
97 - 102
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000359347200009
  • scopus:84939635710
ISSN
0939-5075
DOI
10.1515/znc-2015-5005
language
English
LU publication?
yes
id
7efeefa6-e900-4947-882d-964899c0f21d (old id 7975614)
date added to LUP
2015-09-25 07:11:16
date last changed
2017-11-05 04:10:50
@article{7efeefa6-e900-4947-882d-964899c0f21d,
  abstract     = {Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.},
  author       = {Aqueveque, Pedro and Leonardo Cespedes, Carlos and Becerra, Jose and Davila, Marcelo and Sterner, Olov},
  issn         = {0939-5075},
  keyword      = {antibacterial activity,MIC,MS-3,Stereum rameale,vibralactone},
  language     = {eng},
  number       = {3-4},
  pages        = {97--102},
  publisher    = {Verlag der Zeitschrift für Naturforschung},
  series       = {Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences},
  title        = {Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale},
  url          = {http://dx.doi.org/10.1515/znc-2015-5005},
  volume       = {70},
  year         = {2015},
}