Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

Aqueveque, Pedro ; Leonardo Cespedes, Carlos ; Becerra, Jose ; Davila, Marcelo and Sterner, Olov LU (2015) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 70(3-4). p.97-102
Abstract
Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2... (More)
Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibacterial activity, MIC, MS-3, Stereum rameale, vibralactone
in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
70
issue
3-4
pages
97 - 102
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000359347200009
  • scopus:84939635710
  • pmid:26020559
ISSN
0939-5075
DOI
10.1515/znc-2015-5005
language
English
LU publication?
yes
id
7efeefa6-e900-4947-882d-964899c0f21d (old id 7975614)
date added to LUP
2016-04-01 14:32:14
date last changed
2022-01-28 01:08:26
@article{7efeefa6-e900-4947-882d-964899c0f21d,
  abstract     = {{Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.}},
  author       = {{Aqueveque, Pedro and Leonardo Cespedes, Carlos and Becerra, Jose and Davila, Marcelo and Sterner, Olov}},
  issn         = {{0939-5075}},
  keywords     = {{antibacterial activity; MIC; MS-3; Stereum rameale; vibralactone}},
  language     = {{eng}},
  number       = {{3-4}},
  pages        = {{97--102}},
  publisher    = {{Verlag der Zeitschrift für Naturforschung}},
  series       = {{Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences}},
  title        = {{Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale}},
  url          = {{http://dx.doi.org/10.1515/znc-2015-5005}},
  doi          = {{10.1515/znc-2015-5005}},
  volume       = {{70}},
  year         = {{2015}},
}