Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale
(2015) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 70(3-4). p.97-102- Abstract
- Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2... (More)
- Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively. (Less)
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https://lup.lub.lu.se/record/7975614
- author
- Aqueveque, Pedro ; Leonardo Cespedes, Carlos ; Becerra, Jose ; Davila, Marcelo and Sterner, Olov LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antibacterial activity, MIC, MS-3, Stereum rameale, vibralactone
- in
- Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
- volume
- 70
- issue
- 3-4
- pages
- 97 - 102
- publisher
- Verlag der Zeitschrift für Naturforschung
- external identifiers
-
- wos:000359347200009
- scopus:84939635710
- pmid:26020559
- ISSN
- 0939-5075
- DOI
- 10.1515/znc-2015-5005
- language
- English
- LU publication?
- yes
- id
- 7efeefa6-e900-4947-882d-964899c0f21d (old id 7975614)
- date added to LUP
- 2016-04-01 14:32:14
- date last changed
- 2022-01-28 01:08:26
@article{7efeefa6-e900-4947-882d-964899c0f21d, abstract = {{Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.}}, author = {{Aqueveque, Pedro and Leonardo Cespedes, Carlos and Becerra, Jose and Davila, Marcelo and Sterner, Olov}}, issn = {{0939-5075}}, keywords = {{antibacterial activity; MIC; MS-3; Stereum rameale; vibralactone}}, language = {{eng}}, number = {{3-4}}, pages = {{97--102}}, publisher = {{Verlag der Zeitschrift für Naturforschung}}, series = {{Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences}}, title = {{Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale}}, url = {{http://dx.doi.org/10.1515/znc-2015-5005}}, doi = {{10.1515/znc-2015-5005}}, volume = {{70}}, year = {{2015}}, }