Advanced

A Common Variant in the MTNR1B Gene Is Associated with Increased Risk of Impaired Fasting Glucose (IFG) in Youth with Obesity

Zheng, Chao; Dalla Man, Chiara; Cobelli, Claudio; Groop, Leif LU ; Zhao, Hongyu; Bale, Allen E.; Shaw, Melissa; Duran, Elvira; Pierpont, Bridget and Caprio, Sonia, et al. (2015) In Obesity 23(5). p.1022-1029
Abstract
Objective: To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired fasting glucose (IFG) in obese adolescents. Methods: A total of 346 Caucasians, 218 African-Americans, and 217 Hispanics obese children and adolescents underwent an oral glucose tolerance test (OGTT) and 518 underwent the evaluation of insulin secretion by the oral minimal model (OMM). Also, 274 subjects underwent a second OGTT after 3.0 -/+ 2.1years. Results: The MTNR1B rs10830963 variant was associated with higher fasting glucose levels and lower dynamic beta-cell response in Caucasians and Hispanics (P<0.05) and conferred an increased risk of showing IFG to Caucasians (P=0.05), African-Americans (P=0.0066), and Hispanics... (More)
Objective: To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired fasting glucose (IFG) in obese adolescents. Methods: A total of 346 Caucasians, 218 African-Americans, and 217 Hispanics obese children and adolescents underwent an oral glucose tolerance test (OGTT) and 518 underwent the evaluation of insulin secretion by the oral minimal model (OMM). Also, 274 subjects underwent a second OGTT after 3.0 -/+ 2.1years. Results: The MTNR1B rs10830963 variant was associated with higher fasting glucose levels and lower dynamic beta-cell response in Caucasians and Hispanics (P<0.05) and conferred an increased risk of showing IFG to Caucasians (P=0.05), African-Americans (P=0.0066), and Hispanics (P=0.024). Despite the association between the G6PC2 rs560887 and higher fasting glucose levels (P<0.05), there was no association between this variant and IFG at baseline or at follow-up (all P > 0.10). Conclusions: It has been shown for the first time in obese youth that the MTNR1B variant is associated with an increased risk of IFG. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
23
issue
5
pages
1022 - 1029
publisher
Nature Publishing Group
external identifiers
  • wos:000353964200029
  • scopus:84928544326
ISSN
1930-739X
DOI
10.1002/oby.21030
language
English
LU publication?
yes
id
28cccbfd-2ec8-4201-8e8e-da540b6f17ee (old id 7975683)
date added to LUP
2015-10-01 07:35:30
date last changed
2017-10-29 03:08:12
@article{28cccbfd-2ec8-4201-8e8e-da540b6f17ee,
  abstract     = {Objective: To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired fasting glucose (IFG) in obese adolescents. Methods: A total of 346 Caucasians, 218 African-Americans, and 217 Hispanics obese children and adolescents underwent an oral glucose tolerance test (OGTT) and 518 underwent the evaluation of insulin secretion by the oral minimal model (OMM). Also, 274 subjects underwent a second OGTT after 3.0 -/+ 2.1years. Results: The MTNR1B rs10830963 variant was associated with higher fasting glucose levels and lower dynamic beta-cell response in Caucasians and Hispanics (P&lt;0.05) and conferred an increased risk of showing IFG to Caucasians (P=0.05), African-Americans (P=0.0066), and Hispanics (P=0.024). Despite the association between the G6PC2 rs560887 and higher fasting glucose levels (P&lt;0.05), there was no association between this variant and IFG at baseline or at follow-up (all P &gt; 0.10). Conclusions: It has been shown for the first time in obese youth that the MTNR1B variant is associated with an increased risk of IFG.},
  author       = {Zheng, Chao and Dalla Man, Chiara and Cobelli, Claudio and Groop, Leif and Zhao, Hongyu and Bale, Allen E. and Shaw, Melissa and Duran, Elvira and Pierpont, Bridget and Caprio, Sonia and Santoro, Nicola},
  issn         = {1930-739X},
  language     = {eng},
  number       = {5},
  pages        = {1022--1029},
  publisher    = {Nature Publishing Group},
  series       = {Obesity},
  title        = {A Common Variant in the MTNR1B Gene Is Associated with Increased Risk of Impaired Fasting Glucose (IFG) in Youth with Obesity},
  url          = {http://dx.doi.org/10.1002/oby.21030},
  volume       = {23},
  year         = {2015},
}