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A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain

Choi, Minee L; Begeti, Faye; Barker, Roger A LU and Kim, Namho (2016) In Hippocampus 26(4). p.29-517
Abstract

Adult hippocampal neurogenesis is a highly dynamic process in which new cells are born, but only some of which survive. Of late it has become clear that these surviving newborn neurons have functional roles, most notably in certain forms of memory. Conventional methods to look at adult neurogenesis are based on the quantification of the number of newly born neurons using a simple cell counting methodology. However, this type of approach fails to capture the dynamic aspects of the neurogenic process, where neural proliferation, death and differentiation take place continuously and simultaneously. In this paper, we propose a simple mathematical approach to better understand the adult neurogenic process in the hippocampus which in turn... (More)

Adult hippocampal neurogenesis is a highly dynamic process in which new cells are born, but only some of which survive. Of late it has become clear that these surviving newborn neurons have functional roles, most notably in certain forms of memory. Conventional methods to look at adult neurogenesis are based on the quantification of the number of newly born neurons using a simple cell counting methodology. However, this type of approach fails to capture the dynamic aspects of the neurogenic process, where neural proliferation, death and differentiation take place continuously and simultaneously. In this paper, we propose a simple mathematical approach to better understand the adult neurogenic process in the hippocampus which in turn will allow for a better analysis of this process in disease states and following drug therapies.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article, Research Support, Non-U.S. Gov't
in
Hippocampus
volume
26
issue
4
pages
13 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:84961208534
ISSN
1050-9631
DOI
10.1002/hipo.22541
language
English
LU publication?
no
id
79e41c82-6599-49dd-bce0-18287fb3f5e4
date added to LUP
2016-11-23 13:29:26
date last changed
2017-11-05 05:09:52
@article{79e41c82-6599-49dd-bce0-18287fb3f5e4,
  abstract     = {<p>Adult hippocampal neurogenesis is a highly dynamic process in which new cells are born, but only some of which survive. Of late it has become clear that these surviving newborn neurons have functional roles, most notably in certain forms of memory. Conventional methods to look at adult neurogenesis are based on the quantification of the number of newly born neurons using a simple cell counting methodology. However, this type of approach fails to capture the dynamic aspects of the neurogenic process, where neural proliferation, death and differentiation take place continuously and simultaneously. In this paper, we propose a simple mathematical approach to better understand the adult neurogenic process in the hippocampus which in turn will allow for a better analysis of this process in disease states and following drug therapies.</p>},
  author       = {Choi, Minee L and Begeti, Faye and Barker, Roger A and Kim, Namho},
  issn         = {1050-9631},
  keyword      = {Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {29--517},
  publisher    = {John Wiley & Sons},
  series       = {Hippocampus},
  title        = {A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain},
  url          = {http://dx.doi.org/10.1002/hipo.22541},
  volume       = {26},
  year         = {2016},
}