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Familial risk of urological cancers : data for clinical counseling

Hemminki, Kari LU ; Li, Xinjun LU and Czene, Kamila (2004) In World Journal of Urology 21(6). p.377-381
Abstract

Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR) and 95% confidence limits (CI) were calculated for age-specific familial risk in offspring by an exact proband status. The familial risks for offspring cancer were increased at all urological sites from concordant cancer in the parent and in a sibling proband. The highest SIRs by parent were for testicular and prostate cancer (4.26 and 2.45).... (More)

Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR) and 95% confidence limits (CI) were calculated for age-specific familial risk in offspring by an exact proband status. The familial risks for offspring cancer were increased at all urological sites from concordant cancer in the parent and in a sibling proband. The highest SIRs by parent were for testicular and prostate cancer (4.26 and 2.45). When a sibling was affected, even kidney cancer (4.74) showed a high SIR. For kidney cancers, and also for prostate and testicular cancers, the SIRs were higher among siblings than among offspring and parents, which may indicate the involvement of recessive effects. Family members of patients with prostate cancer or von Hippel Lindau disease can expect organized clinical counseling, but family members of patients with other urological cancers are probably not counseled. Guidelines for clinical counseling or action level should be developed for all urological cancers because of the established familial risks. Urological cancers also offer a challenge to molecular geneticists attempting to identify the susceptibility genes underlying the familial clustering.

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author
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Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Aged, Child, Child, Preschool, Female, Genetic Counseling, Genetic Predisposition to Disease/epidemiology, Genetic Testing, Humans, Infant, Infant, Newborn, Male, Middle Aged, Registries, Sweden/epidemiology, Urologic Neoplasms/diagnosis
in
World Journal of Urology
volume
21
issue
6
pages
5 pages
publisher
Springer
external identifiers
  • scopus:3042766086
ISSN
0724-4983
DOI
10.1007/s00345-003-0375-7
language
English
LU publication?
no
id
7a085506-20d5-48b9-a2cf-5e20ea27c1bb
date added to LUP
2019-01-30 11:46:49
date last changed
2019-03-05 04:31:17
@article{7a085506-20d5-48b9-a2cf-5e20ea27c1bb,
  abstract     = {<p>Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR) and 95% confidence limits (CI) were calculated for age-specific familial risk in offspring by an exact proband status. The familial risks for offspring cancer were increased at all urological sites from concordant cancer in the parent and in a sibling proband. The highest SIRs by parent were for testicular and prostate cancer (4.26 and 2.45). When a sibling was affected, even kidney cancer (4.74) showed a high SIR. For kidney cancers, and also for prostate and testicular cancers, the SIRs were higher among siblings than among offspring and parents, which may indicate the involvement of recessive effects. Family members of patients with prostate cancer or von Hippel Lindau disease can expect organized clinical counseling, but family members of patients with other urological cancers are probably not counseled. Guidelines for clinical counseling or action level should be developed for all urological cancers because of the established familial risks. Urological cancers also offer a challenge to molecular geneticists attempting to identify the susceptibility genes underlying the familial clustering.</p>},
  author       = {Hemminki, Kari and Li, Xinjun and Czene, Kamila},
  issn         = {0724-4983},
  keyword      = {Adolescent,Adult,Aged,Child,Child, Preschool,Female,Genetic Counseling,Genetic Predisposition to Disease/epidemiology,Genetic Testing,Humans,Infant,Infant, Newborn,Male,Middle Aged,Registries,Sweden/epidemiology,Urologic Neoplasms/diagnosis},
  language     = {eng},
  number       = {6},
  pages        = {377--381},
  publisher    = {Springer},
  series       = {World Journal of Urology},
  title        = {Familial risk of urological cancers : data for clinical counseling},
  url          = {http://dx.doi.org/10.1007/s00345-003-0375-7},
  volume       = {21},
  year         = {2004},
}