Interspecies variations in eyeblink conditioning
Domeij, Sofia ; Larsson, Ellie Sandberg ; Gilbert, Mike and Rasmussen, Anders LU
(2025)
In Neuroscience and Biobehavioral Reviews
179.
p.1-7
- Abstract
A central assumption in neuroscience is that learning mechanisms are conserved across species. Eyeblink conditioning, a cornerstone paradigm for studying associative learning and cerebellar function, has been widely used in humans and animal models alike. Yet direct cross-species comparisons remain rare. In this systematic review, we analyzed 484 eyeblink conditioning experiments reported in 271 studies spanning humans, rabbits, rats, mice, as well as individual studies in other species. Our findings reveal consistent interspecies differences in acquisition rates, timing parameters, and stimulus protocols, with notable variation even within species. These results challenge the assumption of mechanistic equivalence across species and... (More)
A central assumption in neuroscience is that learning mechanisms are conserved across species. Eyeblink conditioning, a cornerstone paradigm for studying associative learning and cerebellar function, has been widely used in humans and animal models alike. Yet direct cross-species comparisons remain rare. In this systematic review, we analyzed 484 eyeblink conditioning experiments reported in 271 studies spanning humans, rabbits, rats, mice, as well as individual studies in other species. Our findings reveal consistent interspecies differences in acquisition rates, timing parameters, and stimulus protocols, with notable variation even within species. These results challenge the assumption of mechanistic equivalence across species and highlight the limitations of generalizing neural mechanisms from one species to another.
(Less)
- author
- Domeij, Sofia
; Larsson, Ellie Sandberg
; Gilbert, Mike
and Rasmussen, Anders
LU
- organization
- publishing date
- 2025-10-09
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Neuroscience and Biobehavioral Reviews
- volume
- 179
- article number
- 106398
- pages
- 1 - 7
- publisher
- Elsevier
- external identifiers
-
- pmid:41067328
- scopus:105018052536
- ISSN
- 0149-7634
- DOI
- 10.1016/j.neubiorev.2025.106398
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
- id
- 7a0cb690-40d4-416c-80e9-e370a261b39c
- date added to LUP
- 2025-10-13 07:31:07
- date last changed
- 2025-10-14 12:16:19
@article{7a0cb690-40d4-416c-80e9-e370a261b39c,
abstract = {{<p>A central assumption in neuroscience is that learning mechanisms are conserved across species. Eyeblink conditioning, a cornerstone paradigm for studying associative learning and cerebellar function, has been widely used in humans and animal models alike. Yet direct cross-species comparisons remain rare. In this systematic review, we analyzed 484 eyeblink conditioning experiments reported in 271 studies spanning humans, rabbits, rats, mice, as well as individual studies in other species. Our findings reveal consistent interspecies differences in acquisition rates, timing parameters, and stimulus protocols, with notable variation even within species. These results challenge the assumption of mechanistic equivalence across species and highlight the limitations of generalizing neural mechanisms from one species to another.</p>}},
author = {{Domeij, Sofia and Larsson, Ellie Sandberg and Gilbert, Mike and Rasmussen, Anders}},
issn = {{0149-7634}},
language = {{eng}},
month = {{10}},
pages = {{1--7}},
publisher = {{Elsevier}},
series = {{Neuroscience and Biobehavioral Reviews}},
title = {{Interspecies variations in eyeblink conditioning}},
url = {{http://dx.doi.org/10.1016/j.neubiorev.2025.106398}},
doi = {{10.1016/j.neubiorev.2025.106398}},
volume = {{179}},
year = {{2025}},
}