Alpha-Amylase Inhibits Cell Proliferation and Glucose Uptake in Human Neuroblastoma Cell Lines
Pierzynowska, Kateryna LU
; Thomasson, Sofia
and Oredsson, Stina
LU
(2022)
In BioMed Research International
2022.
- Abstract
The present article describes a study of the effects of alpha-amylase (α-amylase) on the human neuroblastoma (NB) cell lines SH-SY5Y, IMR-32, and LA-N-1. NB is the most common malignancy diagnosed in infants younger than 12 months. Some clinical observations revealed an inverse association between the risk of NB development and breastfeeding. α-Amylase which is present in breast milk was shown to have anticancer properties already in the beginning of the 20th century. Data presented here show that pancreatic α-amylase inhibits cell proliferation and has a direct impact on glucose uptake in the human NB cell lines. Our results point out the importance of further research which could elucidate the α-amylase mode of action and justify the... (More)
The present article describes a study of the effects of alpha-amylase (α-amylase) on the human neuroblastoma (NB) cell lines SH-SY5Y, IMR-32, and LA-N-1. NB is the most common malignancy diagnosed in infants younger than 12 months. Some clinical observations revealed an inverse association between the risk of NB development and breastfeeding. α-Amylase which is present in breast milk was shown to have anticancer properties already in the beginning of the 20th century. Data presented here show that pancreatic α-amylase inhibits cell proliferation and has a direct impact on glucose uptake in the human NB cell lines. Our results point out the importance of further research which could elucidate the α-amylase mode of action and justify the presence of this enzyme in breast milk as a possible inhibitor of NB development. α-Amylase can be thus recognized as a potential safe and natural mild/host anticancer agent minimizing chemotherapy-related toxicity in the treatment of NB.
(Less)
- author
- Pierzynowska, Kateryna
LU
; Thomasson, Sofia
and Oredsson, Stina
LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BioMed Research International
- volume
- 2022
- article number
- 4271358
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:35924266
- scopus:85135501357
- ISSN
- 2314-6133
- DOI
- 10.1155/2022/4271358
- language
- English
- LU publication?
- yes
- id
- 7a2ff0ea-3c00-4a56-ac01-1800012b324e
- date added to LUP
- 2022-09-12 11:58:08
- date last changed
- 2024-04-18 14:05:41
@article{7a2ff0ea-3c00-4a56-ac01-1800012b324e,
abstract = {{<p>The present article describes a study of the effects of alpha-amylase (α-amylase) on the human neuroblastoma (NB) cell lines SH-SY5Y, IMR-32, and LA-N-1. NB is the most common malignancy diagnosed in infants younger than 12 months. Some clinical observations revealed an inverse association between the risk of NB development and breastfeeding. α-Amylase which is present in breast milk was shown to have anticancer properties already in the beginning of the 20th century. Data presented here show that pancreatic α-amylase inhibits cell proliferation and has a direct impact on glucose uptake in the human NB cell lines. Our results point out the importance of further research which could elucidate the α-amylase mode of action and justify the presence of this enzyme in breast milk as a possible inhibitor of NB development. α-Amylase can be thus recognized as a potential safe and natural mild/host anticancer agent minimizing chemotherapy-related toxicity in the treatment of NB. </p>}},
author = {{Pierzynowska, Kateryna and Thomasson, Sofia and Oredsson, Stina}},
issn = {{2314-6133}},
language = {{eng}},
publisher = {{Hindawi Limited}},
series = {{BioMed Research International}},
title = {{Alpha-Amylase Inhibits Cell Proliferation and Glucose Uptake in Human Neuroblastoma Cell Lines}},
url = {{http://dx.doi.org/10.1155/2022/4271358}},
doi = {{10.1155/2022/4271358}},
volume = {{2022}},
year = {{2022}},
}