Long-Term Outcome Following Coronary Artery Stenting by History of Preterm Delivery
Pehrson, Moa LU ; Edsfeldt, Andreas LU ; Sarno, Giovanna ; Fraser, Abigail ; Rich-Edwards, Janet W. ; Pihlsgård, Mats LU and Timpka, Simon LU
(2022)
In JACC: Advances
1(5).
- Abstract
- Background
Women are at a greater risk of a major adverse cardiovascular event (MACE) after percutaneous coronary intervention than men. A history of preterm delivery is a female-specific risk factor for coronary artery disease, but its relevance in the treatment of coronary artery disease is unknown.
Objectives
The purpose of this study was to analyze the association between a history of preterm delivery and MACE after the first coronary artery stenting.
Methods
We included a nationwide sample of 5,766 Swedish women aged ≤65 years receiving their first coronary stent during 2006 to 2017. To adjust for periprocedural characteristics and estimate the association between a history of preterm delivery and MACE at >30... (More) - Background
Women are at a greater risk of a major adverse cardiovascular event (MACE) after percutaneous coronary intervention than men. A history of preterm delivery is a female-specific risk factor for coronary artery disease, but its relevance in the treatment of coronary artery disease is unknown.
Objectives
The purpose of this study was to analyze the association between a history of preterm delivery and MACE after the first coronary artery stenting.
Methods
We included a nationwide sample of 5,766 Swedish women aged ≤65 years receiving their first coronary stent during 2006 to 2017. To adjust for periprocedural characteristics and estimate the association between a history of preterm delivery and MACE at >30 days from stenting, we used proportional hazards regression. We also investigated mortality by history of preterm delivery.
Results
During a median follow-up time of 3.7 years (IQR: 1.3-6.7 years), 1,200 (20.8%) women had a MACE. In total, 963 (16.7%) women had a history of preterm delivery. A history of preterm delivery was associated with a higher risk of MACE (adjusted HR: 1.19; 95% CI: 1.03-1.38) and mortality (adjusted HR ratio: 1.38; 95% CI: 1.02-1.85). Similar associations were observed when excluding women with a history of hypertensive disorders of pregnancy or diabetes. Subgroup analyses suggested that women with a history of early preterm delivery had lower risk of MACE than those who had late preterm delivery (P = 0.04).
Conclusions
History of preterm delivery is associated with worse prognosis following the first coronary artery stenting in women and warrants consideration as a risk factor also in the secondary prevention setting. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7a569f6d-f09e-4ecb-a8cd-e4618eff1cb6
- author
- Pehrson, Moa
LU
; Edsfeldt, Andreas
LU
; Sarno, Giovanna
; Fraser, Abigail
; Rich-Edwards, Janet W.
; Pihlsgård, Mats
LU
and Timpka, Simon
LU
- organization
- publishing date
- 2022-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- JACC: Advances
- volume
- 1
- issue
- 5
- article number
- 100142
- publisher
- American College of Cardiology
- external identifiers
-
- scopus:85152169553
- ISSN
- 2772-963X
- DOI
- 10.1016/j.jacadv.2022.100142
- language
- English
- LU publication?
- yes
- id
- 7a569f6d-f09e-4ecb-a8cd-e4618eff1cb6
- date added to LUP
- 2023-02-08 08:47:13
- date last changed
- 2024-03-13 09:52:56
@article{7a569f6d-f09e-4ecb-a8cd-e4618eff1cb6,
abstract = {{Background<br/>Women are at a greater risk of a major adverse cardiovascular event (MACE) after percutaneous coronary intervention than men. A history of preterm delivery is a female-specific risk factor for coronary artery disease, but its relevance in the treatment of coronary artery disease is unknown.<br/>Objectives<br/>The purpose of this study was to analyze the association between a history of preterm delivery and MACE after the first coronary artery stenting.<br/>Methods<br/>We included a nationwide sample of 5,766 Swedish women aged ≤65 years receiving their first coronary stent during 2006 to 2017. To adjust for periprocedural characteristics and estimate the association between a history of preterm delivery and MACE at >30 days from stenting, we used proportional hazards regression. We also investigated mortality by history of preterm delivery.<br/>Results<br/>During a median follow-up time of 3.7 years (IQR: 1.3-6.7 years), 1,200 (20.8%) women had a MACE. In total, 963 (16.7%) women had a history of preterm delivery. A history of preterm delivery was associated with a higher risk of MACE (adjusted HR: 1.19; 95% CI: 1.03-1.38) and mortality (adjusted HR ratio: 1.38; 95% CI: 1.02-1.85). Similar associations were observed when excluding women with a history of hypertensive disorders of pregnancy or diabetes. Subgroup analyses suggested that women with a history of early preterm delivery had lower risk of MACE than those who had late preterm delivery (P = 0.04).<br/>Conclusions<br/>History of preterm delivery is associated with worse prognosis following the first coronary artery stenting in women and warrants consideration as a risk factor also in the secondary prevention setting.}},
author = {{Pehrson, Moa and Edsfeldt, Andreas and Sarno, Giovanna and Fraser, Abigail and Rich-Edwards, Janet W. and Pihlsgård, Mats and Timpka, Simon}},
issn = {{2772-963X}},
language = {{eng}},
month = {{12}},
number = {{5}},
publisher = {{American College of Cardiology}},
series = {{JACC: Advances}},
title = {{Long-Term Outcome Following Coronary Artery Stenting by History of Preterm Delivery}},
url = {{http://dx.doi.org/10.1016/j.jacadv.2022.100142}},
doi = {{10.1016/j.jacadv.2022.100142}},
volume = {{1}},
year = {{2022}},
}