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Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity

Niinistö, Sari ; Erlund, Iris ; Lee, Hye-Seung ; Uusitalo, Ulla ; Salminen, Irma ; Aronsson, Carin Andrén LU orcid ; Parikh, Hemang M LU ; Liu, Xiang ; Hummel, Sandra and Toppari, Jorma , et al. (2021) In Scientific Reports 11(1).
Abstract

Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case-control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and... (More)

Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case-control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n - 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n - 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
11
issue
1
article number
3627
publisher
Nature Publishing Group
external identifiers
  • scopus:85101050436
  • pmid:33574451
ISSN
2045-2322
DOI
10.1038/s41598-021-82200-9
language
English
LU publication?
yes
additional info
These authors jointly supervised this work: Jill M. Norris and Suvi M. Virtanen
id
7a7aa851-390d-48c9-985b-aa493a6c6ce1
date added to LUP
2021-02-17 01:37:08
date last changed
2022-05-24 04:50:13
@article{7a7aa851-390d-48c9-985b-aa493a6c6ce1,
  abstract     = {{<p>Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case-control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n - 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n - 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.</p>}},
  author       = {{Niinistö, Sari and Erlund, Iris and Lee, Hye-Seung and Uusitalo, Ulla and Salminen, Irma and Aronsson, Carin Andrén and Parikh, Hemang M and Liu, Xiang and Hummel, Sandra and Toppari, Jorma and She, Jin-Xiong and Lernmark, Åke and Ziegler, Annette G and Rewers, Marian and Akolkar, Beena and Krischer, Jeffrey P and Galas, David and Das, Siba and Sakhanenko, Nikita and Rich, Stephen S and Hagopian, William and Norris, Jill M and Virtanen, Suvi M}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity}},
  url          = {{http://dx.doi.org/10.1038/s41598-021-82200-9}},
  doi          = {{10.1038/s41598-021-82200-9}},
  volume       = {{11}},
  year         = {{2021}},
}