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Estimating the parameters of the operational model of pharmacological agonism

Frigyesi, Attila LU and Hössjer, Ola LU (2006) In Statistics in Medicine 25(17). p.2932-2945
Abstract
The aim of this work is practical. We show that the parameters of the widely used operational model of pharmacological agonism are difficult to estimate from single dose-response curves. The parameters can be estimated using pairs of dose-response curves (usually treatment and control) sharing some parameters. Confidence bands for the estimators are developed. In the case of multiple dose-response curve pairs one can employ a non-linear mixed effects model to allow for inter-individual variation. The point estimates and the confidence intervals thus obtained are similar to the more naive construction based on mean and standard errors of parameter estimates. To test for difference of certain parameters between treatment and control we... (More)
The aim of this work is practical. We show that the parameters of the widely used operational model of pharmacological agonism are difficult to estimate from single dose-response curves. The parameters can be estimated using pairs of dose-response curves (usually treatment and control) sharing some parameters. Confidence bands for the estimators are developed. In the case of multiple dose-response curve pairs one can employ a non-linear mixed effects model to allow for inter-individual variation. The point estimates and the confidence intervals thus obtained are similar to the more naive construction based on mean and standard errors of parameter estimates. To test for difference of certain parameters between treatment and control we employ a permutation test and Wald's test. Copyright (c) 2005 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
confidence interval, of pharmacological agonism, operational model, dose-response curves, concentration-response curves, mixed effects
in
Statistics in Medicine
volume
25
issue
17
pages
2932 - 2945
publisher
John Wiley & Sons
external identifiers
  • wos:000240047100005
  • scopus:33747616407
ISSN
1097-0258
DOI
10.1002/sim.2448
language
English
LU publication?
yes
id
7a824f06-2dc8-47e1-9425-c3cc150f9d84 (old id 394942)
date added to LUP
2007-10-03 07:46:31
date last changed
2019-03-08 01:38:30
@article{7a824f06-2dc8-47e1-9425-c3cc150f9d84,
  abstract     = {The aim of this work is practical. We show that the parameters of the widely used operational model of pharmacological agonism are difficult to estimate from single dose-response curves. The parameters can be estimated using pairs of dose-response curves (usually treatment and control) sharing some parameters. Confidence bands for the estimators are developed. In the case of multiple dose-response curve pairs one can employ a non-linear mixed effects model to allow for inter-individual variation. The point estimates and the confidence intervals thus obtained are similar to the more naive construction based on mean and standard errors of parameter estimates. To test for difference of certain parameters between treatment and control we employ a permutation test and Wald's test. Copyright (c) 2005 John Wiley & Sons, Ltd.},
  author       = {Frigyesi, Attila and Hössjer, Ola},
  issn         = {1097-0258},
  keyword      = {confidence interval,of pharmacological agonism,operational model,dose-response curves,concentration-response curves,mixed effects},
  language     = {eng},
  number       = {17},
  pages        = {2932--2945},
  publisher    = {John Wiley & Sons},
  series       = {Statistics in Medicine},
  title        = {Estimating the parameters of the operational model of pharmacological agonism},
  url          = {http://dx.doi.org/10.1002/sim.2448},
  volume       = {25},
  year         = {2006},
}