Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery
Paulsson, Kajsa M LU
(2004)
In Cellular and Molecular Life Sciences
61(19-20).
p.2446-2460
- Abstract
- Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components... (More)
- Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself. These are of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1297828
- author
- Paulsson, Kajsa M
LU
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cellular and Molecular Life Sciences
- volume
- 61
- issue
- 19-20
- pages
- 2446 - 2460
- publisher
- Birkhäuser Verlag
- external identifiers
-
- wos:000224888600005
- scopus:9744262548
- ISSN
- 1420-9071
- DOI
- 10.1007/s00018-004-4113-0
- language
- English
- LU publication?
- no
- id
- 7ab17b0d-de93-4563-85ee-de1f9b46b367 (old id 1297828)
- date added to LUP
- 2016-04-01 16:53:37
- date last changed
- 2022-01-28 22:55:42
@article{7ab17b0d-de93-4563-85ee-de1f9b46b367,
abstract = {{Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself. These are of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general.}},
author = {{Paulsson, Kajsa M}},
issn = {{1420-9071}},
language = {{eng}},
number = {{19-20}},
pages = {{2446--2460}},
publisher = {{Birkhäuser Verlag}},
series = {{Cellular and Molecular Life Sciences}},
title = {{Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery}},
url = {{http://dx.doi.org/10.1007/s00018-004-4113-0}},
doi = {{10.1007/s00018-004-4113-0}},
volume = {{61}},
year = {{2004}},
}