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Tuning the Emission of Bis-ethylenedioxythiophene-thiophenes upon Aggregation

Sahalianov, Ihor ; Abrahamsson, Tobias ; Priyadarshini, Diana ; Mousa, Abdelrazek H. LU ; Arja, Katriann ; Gerasimov, Jennifer Y. ; Linares, Mathieu ; Simon, Daniel T. ; Olsson, Roger LU orcid and Baryshnikov, Glib , et al. (2024) In Journal of Physical Chemistry B 128(27). p.6581-6588
Abstract

The ability of small lipophilic molecules to penetrate the blood-brain barrier through transmembrane diffusion has enabled researchers to explore new diagnostics and therapies for brain disorders. Until now, therapies targeting the brain have mainly relied on biochemical mechanisms, while electrical treatments such as deep brain stimulation often require invasive procedures. An alternative to implanting deep brain stimulation probes could involve administering small molecule precursors intravenously, capable of crossing the blood-brain barrier, and initiating the formation of conductive polymer networks in the brain through in vivo polymerization. This study examines the aggregation behavior of five water-soluble conducting polymer... (More)

The ability of small lipophilic molecules to penetrate the blood-brain barrier through transmembrane diffusion has enabled researchers to explore new diagnostics and therapies for brain disorders. Until now, therapies targeting the brain have mainly relied on biochemical mechanisms, while electrical treatments such as deep brain stimulation often require invasive procedures. An alternative to implanting deep brain stimulation probes could involve administering small molecule precursors intravenously, capable of crossing the blood-brain barrier, and initiating the formation of conductive polymer networks in the brain through in vivo polymerization. This study examines the aggregation behavior of five water-soluble conducting polymer precursors sharing the same conjugate core but differing in side chains, using spectroscopy and various computational chemistry tools. Our findings highlight the significant impact of side chain composition on both aggregation and spectroscopic response.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Physical Chemistry B
volume
128
issue
27
pages
8 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:38942741
  • scopus:85197077745
ISSN
1520-6106
DOI
10.1021/acs.jpcb.4c02891
language
English
LU publication?
yes
id
7b283892-f277-4bab-997b-5e0187fd0af5
date added to LUP
2024-09-24 14:11:06
date last changed
2025-07-02 16:56:10
@article{7b283892-f277-4bab-997b-5e0187fd0af5,
  abstract     = {{<p>The ability of small lipophilic molecules to penetrate the blood-brain barrier through transmembrane diffusion has enabled researchers to explore new diagnostics and therapies for brain disorders. Until now, therapies targeting the brain have mainly relied on biochemical mechanisms, while electrical treatments such as deep brain stimulation often require invasive procedures. An alternative to implanting deep brain stimulation probes could involve administering small molecule precursors intravenously, capable of crossing the blood-brain barrier, and initiating the formation of conductive polymer networks in the brain through in vivo polymerization. This study examines the aggregation behavior of five water-soluble conducting polymer precursors sharing the same conjugate core but differing in side chains, using spectroscopy and various computational chemistry tools. Our findings highlight the significant impact of side chain composition on both aggregation and spectroscopic response.</p>}},
  author       = {{Sahalianov, Ihor and Abrahamsson, Tobias and Priyadarshini, Diana and Mousa, Abdelrazek H. and Arja, Katriann and Gerasimov, Jennifer Y. and Linares, Mathieu and Simon, Daniel T. and Olsson, Roger and Baryshnikov, Glib and Berggren, Magnus and Musumeci, Chiara}},
  issn         = {{1520-6106}},
  language     = {{eng}},
  number       = {{27}},
  pages        = {{6581--6588}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Physical Chemistry B}},
  title        = {{Tuning the Emission of Bis-ethylenedioxythiophene-thiophenes upon Aggregation}},
  url          = {{http://dx.doi.org/10.1021/acs.jpcb.4c02891}},
  doi          = {{10.1021/acs.jpcb.4c02891}},
  volume       = {{128}},
  year         = {{2024}},
}