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Prognostic impact of tumour-associated B cells and plasma cells in oesophageal and gastric adenocarcinoma

Fristedt, Richard LU ; Borg, David LU ; Hedner, Charlotta LU ; Berntsson, Jonna LU ; Nodin, Björn LU ; Eberhard, Jakob LU ; Micke, Patrick and Jirström, Karin LU (2016) In Journal of Gastrointestinal Oncology 7(6). p.848-859
Abstract

Background: While it is well established that the cell-mediated immune response plays an important role in cancer progression and spread, the role of the humoral immune response in this regard has been less studied. According to the existing literature, dense infiltration of B cells or plasma cells appears to correlate mainly with an improved prognosis in several types of cancer, but their prognostic impact in oesophageal and gastric cancer has not yet been described. Methods: Immunohistochemistry was applied on tissue microarrays (TMA) to assess the stromal density of B cells (CD20+) and plasma cells [CD138+ or immunoglobulin kappa C (IGKC+)] in chemo-/radiotherapy-naive tumours from a consecutive cohort of 174 patients with resected... (More)

Background: While it is well established that the cell-mediated immune response plays an important role in cancer progression and spread, the role of the humoral immune response in this regard has been less studied. According to the existing literature, dense infiltration of B cells or plasma cells appears to correlate mainly with an improved prognosis in several types of cancer, but their prognostic impact in oesophageal and gastric cancer has not yet been described. Methods: Immunohistochemistry was applied on tissue microarrays (TMA) to assess the stromal density of B cells (CD20+) and plasma cells [CD138+ or immunoglobulin kappa C (IGKC+)] in chemo-/radiotherapy-naive tumours from a consecutive cohort of 174 patients with resected oesophageal or gastric adenocarcinoma. Cox proportional hazard's modelling was applied to examine the impact of the investigated markers on overall survival (OS) and time to recurrence (TTR). Results: In curatively treated patients with oesophageal adenocarcinoma, high expression of IGKC was an independent predictor of a prolonged OS [hazard ratio (HR) 0.10; 95% confidence interval (CI), 0.02-0.57], and TTR (HR 0.15; 95% CI, 0.03-0.71). In curatively treated patients with gastric adenocarcinoma, high expression of IGKC independently predicted a prolonged OS (HR 0.46; 95 % CI, 0.24-0.87) and TTR (HR 0.46; 95% CI, 0.21-0.98). Expression of CD20 was not prognostic, and CD138 expression was only prognostic in unadjusted analysis of TTR in gastric cancer. Conclusions: These results demonstrate, for the first time, that abundant infiltration of IGKC+ plasma cells independently predicts a prolonged survival in both oesophageal and gastric cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenocarcinoma, Gastric, Oesophageal, Plasma cells, Prognosis
in
Journal of Gastrointestinal Oncology
volume
7
issue
6
pages
12 pages
publisher
Pioneer Bioscience Publishing Company (PBPC)
external identifiers
  • scopus:85006973022
  • wos:000392548400004
ISSN
2078-6891
DOI
10.21037/jgo.2016.11.07
language
English
LU publication?
yes
id
7bbcb7f1-408c-4a84-ad2d-b07d402c1c5b
date added to LUP
2017-01-19 11:46:46
date last changed
2017-09-18 11:32:34
@article{7bbcb7f1-408c-4a84-ad2d-b07d402c1c5b,
  abstract     = {<p>Background: While it is well established that the cell-mediated immune response plays an important role in cancer progression and spread, the role of the humoral immune response in this regard has been less studied. According to the existing literature, dense infiltration of B cells or plasma cells appears to correlate mainly with an improved prognosis in several types of cancer, but their prognostic impact in oesophageal and gastric cancer has not yet been described. Methods: Immunohistochemistry was applied on tissue microarrays (TMA) to assess the stromal density of B cells (CD20+) and plasma cells [CD138+ or immunoglobulin kappa C (IGKC+)] in chemo-/radiotherapy-naive tumours from a consecutive cohort of 174 patients with resected oesophageal or gastric adenocarcinoma. Cox proportional hazard's modelling was applied to examine the impact of the investigated markers on overall survival (OS) and time to recurrence (TTR). Results: In curatively treated patients with oesophageal adenocarcinoma, high expression of IGKC was an independent predictor of a prolonged OS [hazard ratio (HR) 0.10; 95% confidence interval (CI), 0.02-0.57], and TTR (HR 0.15; 95% CI, 0.03-0.71). In curatively treated patients with gastric adenocarcinoma, high expression of IGKC independently predicted a prolonged OS (HR 0.46; 95 % CI, 0.24-0.87) and TTR (HR 0.46; 95% CI, 0.21-0.98). Expression of CD20 was not prognostic, and CD138 expression was only prognostic in unadjusted analysis of TTR in gastric cancer. Conclusions: These results demonstrate, for the first time, that abundant infiltration of IGKC+ plasma cells independently predicts a prolonged survival in both oesophageal and gastric cancer.</p>},
  author       = {Fristedt, Richard and Borg, David and Hedner, Charlotta and Berntsson, Jonna and Nodin, Björn and Eberhard, Jakob and Micke, Patrick and Jirström, Karin},
  issn         = {2078-6891},
  keyword      = {Adenocarcinoma,Gastric,Oesophageal,Plasma cells,Prognosis},
  language     = {eng},
  number       = {6},
  pages        = {848--859},
  publisher    = {Pioneer Bioscience Publishing Company (PBPC)},
  series       = {Journal of Gastrointestinal Oncology},
  title        = {Prognostic impact of tumour-associated B cells and plasma cells in oesophageal and gastric adenocarcinoma},
  url          = {http://dx.doi.org/10.21037/jgo.2016.11.07},
  volume       = {7},
  year         = {2016},
}