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FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke

Muhammad, Iram Faqir LU ; Borné, Yan LU ; Melander, Olle LU ; Orho-Melander, Marju LU ; Nilsson, Jan LU ; Söderholm, Martin LU and Engström, Gunnar LU (2018) In Stroke 49(9). p.2224-2226
Abstract

Background and Purpose- Apoptosis has been implicated in atherosclerosis and plaque rupture. This population-based study examined the relationship between 3 markers of apoptosis, that is, FADD (Fas-associated protein with death domain), caspase-3, and caspase-8, and incidence of ischemic stroke. Methods- The study population included 4356 participants from the MDCS (Malmö Diet and Cancer Study) cardiovascular cohort, without a history of stroke. Incidence of ischemic stroke was followed by linkages to local and national registers. Cox proportional hazards regression was used to assess the incidence of ischemic stroke in relation to quartiles of FADD, caspase-3, and caspase-8, adjusted for potential confounders. Results- During a mean... (More)

Background and Purpose- Apoptosis has been implicated in atherosclerosis and plaque rupture. This population-based study examined the relationship between 3 markers of apoptosis, that is, FADD (Fas-associated protein with death domain), caspase-3, and caspase-8, and incidence of ischemic stroke. Methods- The study population included 4356 participants from the MDCS (Malmö Diet and Cancer Study) cardiovascular cohort, without a history of stroke. Incidence of ischemic stroke was followed by linkages to local and national registers. Cox proportional hazards regression was used to assess the incidence of ischemic stroke in relation to quartiles of FADD, caspase-3, and caspase-8, adjusted for potential confounders. Results- During a mean follow-up period of 19.5±4.9 years, a total of 321 (7.4%) participants were diagnosed with incident ischemic stroke. Individuals with high levels of FADD and caspase-8 had a significantly increased risk of ischemic stroke, after adjustment for potential confounders. The multivariable-adjusted hazard ratios for Q4 versus Q1-Q3 of FADD and caspase-8 were 1.49 (95% CI, 1.18-1.87; P<0.01) and 1.77 (95% CI, 1.41-2.22; P<0.001), respectively. The hazard ratios per 1-SD increment of FADD and caspase-8 were 1.27 (95% CI, 1.14-1.41) and 1.31 (95% CI, 1.18-1.45), respectively. No association was observed for caspase-3 with ischemic stroke. Conclusions- Elevated levels of FADD and caspase-8, but not caspase-3, are associated with increased incidence of ischemic stroke.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
apoptosis, humans, incidence, risk, stroke
in
Stroke
volume
49
issue
9
pages
3 pages
publisher
American Heart Association
external identifiers
  • scopus:85055604502
ISSN
1524-4628
DOI
10.1161/STROKEAHA.118.022063
language
English
LU publication?
yes
id
7bd7b4ea-f38d-492e-a58d-cae85803d5db
date added to LUP
2018-11-16 12:46:52
date last changed
2019-02-20 11:36:21
@article{7bd7b4ea-f38d-492e-a58d-cae85803d5db,
  abstract     = {<p>Background and Purpose- Apoptosis has been implicated in atherosclerosis and plaque rupture. This population-based study examined the relationship between 3 markers of apoptosis, that is, FADD (Fas-associated protein with death domain), caspase-3, and caspase-8, and incidence of ischemic stroke. Methods- The study population included 4356 participants from the MDCS (Malmö Diet and Cancer Study) cardiovascular cohort, without a history of stroke. Incidence of ischemic stroke was followed by linkages to local and national registers. Cox proportional hazards regression was used to assess the incidence of ischemic stroke in relation to quartiles of FADD, caspase-3, and caspase-8, adjusted for potential confounders. Results- During a mean follow-up period of 19.5±4.9 years, a total of 321 (7.4%) participants were diagnosed with incident ischemic stroke. Individuals with high levels of FADD and caspase-8 had a significantly increased risk of ischemic stroke, after adjustment for potential confounders. The multivariable-adjusted hazard ratios for Q4 versus Q1-Q3 of FADD and caspase-8 were 1.49 (95% CI, 1.18-1.87; P&lt;0.01) and 1.77 (95% CI, 1.41-2.22; P&lt;0.001), respectively. The hazard ratios per 1-SD increment of FADD and caspase-8 were 1.27 (95% CI, 1.14-1.41) and 1.31 (95% CI, 1.18-1.45), respectively. No association was observed for caspase-3 with ischemic stroke. Conclusions- Elevated levels of FADD and caspase-8, but not caspase-3, are associated with increased incidence of ischemic stroke.</p>},
  author       = {Muhammad, Iram Faqir and Borné, Yan and Melander, Olle and Orho-Melander, Marju and Nilsson, Jan and Söderholm, Martin and Engström, Gunnar},
  issn         = {1524-4628},
  keyword      = {apoptosis,humans,incidence,risk,stroke},
  language     = {eng},
  number       = {9},
  pages        = {2224--2226},
  publisher    = {American Heart Association},
  series       = {Stroke},
  title        = {FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.118.022063},
  volume       = {49},
  year         = {2018},
}