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Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor

Puls, Florian ; Carter, Jodi M. ; Pillay, Nischalan ; McCulloch, Thomas A. ; Sumathi, Vaiyapuri P. ; Rissler, Pehr LU ; Fagman, Henrik ; Hansson, Magnus ; Amary, Fernanda and Tirabosco, Roberto , et al. (2022) In Modern Pathology 35(6). p.767-776
Abstract

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a recently recognized soft tissue tumor that is considered to be of borderline malignancy. The pathogenesis of this tumor remains incompletely understood, but it has been suggested that SCD34FT overlaps with tumors showing fusions involving the PRDM10 gene. Previous analyses of PRDM10-rearranged tumors have demonstrated that they have a distinct gene expression profile, resulting in high expression of CADM3 (also known as SynCam3), which can be detected immunohistochemically. Here, we investigated a series (n = 43) of SCD34FT or PRDM10-rearranged tumors and potential mimics (n = 226) with regard to morphological, genetic, and immunohistochemical features. The results show that... (More)

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a recently recognized soft tissue tumor that is considered to be of borderline malignancy. The pathogenesis of this tumor remains incompletely understood, but it has been suggested that SCD34FT overlaps with tumors showing fusions involving the PRDM10 gene. Previous analyses of PRDM10-rearranged tumors have demonstrated that they have a distinct gene expression profile, resulting in high expression of CADM3 (also known as SynCam3), which can be detected immunohistochemically. Here, we investigated a series (n = 43) of SCD34FT or PRDM10-rearranged tumors and potential mimics (n = 226) with regard to morphological, genetic, and immunohistochemical features. The results show that SCD34FT and PRDM10-rearranged tumor are morphologically indistinguishable; 41 of 43 tumors of both entities are CADM3-positive. Hence, we suggest that they constitute a single entity, preferably referred to as SCD34FT. Expression of CADM3 was only rarely seen in other soft tissue tumors, except in tumors with Schwann cell differentiation. Thus, IHC for CADM3, in combination with the characteristic morphological features, is a valuable adjunct in the diagnosis of SCD34FT.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Modern Pathology
volume
35
issue
6
pages
767 - 776
publisher
Nature Publishing Group
external identifiers
  • pmid:34969957
  • scopus:85122084603
ISSN
0893-3952
DOI
10.1038/s41379-021-00991-8
language
English
LU publication?
yes
id
7bde6bf3-77ed-491d-926a-efbc7a69425b
date added to LUP
2022-03-23 11:42:28
date last changed
2025-03-16 23:07:11
@article{7bde6bf3-77ed-491d-926a-efbc7a69425b,
  abstract     = {{<p>Superficial CD34-positive fibroblastic tumor (SCD34FT) is a recently recognized soft tissue tumor that is considered to be of borderline malignancy. The pathogenesis of this tumor remains incompletely understood, but it has been suggested that SCD34FT overlaps with tumors showing fusions involving the PRDM10 gene. Previous analyses of PRDM10-rearranged tumors have demonstrated that they have a distinct gene expression profile, resulting in high expression of CADM3 (also known as SynCam3), which can be detected immunohistochemically. Here, we investigated a series (n = 43) of SCD34FT or PRDM10-rearranged tumors and potential mimics (n = 226) with regard to morphological, genetic, and immunohistochemical features. The results show that SCD34FT and PRDM10-rearranged tumor are morphologically indistinguishable; 41 of 43 tumors of both entities are CADM3-positive. Hence, we suggest that they constitute a single entity, preferably referred to as SCD34FT. Expression of CADM3 was only rarely seen in other soft tissue tumors, except in tumors with Schwann cell differentiation. Thus, IHC for CADM3, in combination with the characteristic morphological features, is a valuable adjunct in the diagnosis of SCD34FT.</p>}},
  author       = {{Puls, Florian and Carter, Jodi M. and Pillay, Nischalan and McCulloch, Thomas A. and Sumathi, Vaiyapuri P. and Rissler, Pehr and Fagman, Henrik and Hansson, Magnus and Amary, Fernanda and Tirabosco, Roberto and Magnusson, Linda and Nilsson, Jenny and Flanagan, Adrienne M. and Folpe, Andrew L. and Mertens, Fredrik}},
  issn         = {{0893-3952}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{767--776}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Modern Pathology}},
  title        = {{Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor}},
  url          = {{http://dx.doi.org/10.1038/s41379-021-00991-8}},
  doi          = {{10.1038/s41379-021-00991-8}},
  volume       = {{35}},
  year         = {{2022}},
}