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Exploring new prognostic biomarkers in Mantle Cell Lymphoma : a comparison of the circSCORE and the MCL35 score

Salim, Ruth ; Husby, Simon ; Winther Eskelund, Christian ; Scott, David W. ; Holte, Harald ; Kolstad, Arne ; Räty, Riikka ; Ek, Sara LU ; Jerkeman, Mats LU and Geisler, Christian , et al. (2023) In Leukemia and Lymphoma 64(8). p.1414-1423
Abstract

Mantle cell lymphoma (MCL) is a biologically and clinically heterogeneous disease, emphasizing the need for prognostic biomarkers. In this study we aimed at comparing the prognostic value of two RNA-based risk scores, circSCORE and MCL35, in 149 patients from the MCL2 (ISRCTN87866680) and MCL3 (NCT00514475) patient cohorts. Both risk scores provided significant stratification of high versus low risk for progression free survival (PFS) and overall survival (OS). The circSCORE retained significant prognostic value in adjusted multivariable Cox regressions for PFS, but not for OS. Furthermore, circSCORE added significant prognostic value to MIPI in the pooled cohort (MCL2 and MCL3) for PFS and OS, and for PFS in MCL3 alone, outperforming... (More)

Mantle cell lymphoma (MCL) is a biologically and clinically heterogeneous disease, emphasizing the need for prognostic biomarkers. In this study we aimed at comparing the prognostic value of two RNA-based risk scores, circSCORE and MCL35, in 149 patients from the MCL2 (ISRCTN87866680) and MCL3 (NCT00514475) patient cohorts. Both risk scores provided significant stratification of high versus low risk for progression free survival (PFS) and overall survival (OS). The circSCORE retained significant prognostic value in adjusted multivariable Cox regressions for PFS, but not for OS. Furthermore, circSCORE added significant prognostic value to MIPI in the pooled cohort (MCL2 and MCL3) for PFS and OS, and for PFS in MCL3 alone, outperforming Ki67 and MCL35. We suggest a new, combined MIPI-circSCORE with improved prognostic value, and with potential for future clinical implementation, if validated in a larger, independent cohort.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
circRNA, circSCORE, Mantle cell lymphoma, MCL35, mRNA, prognostic biomarkers
in
Leukemia and Lymphoma
volume
64
issue
8
pages
10 pages
publisher
Taylor & Francis
external identifiers
  • pmid:37259807
  • scopus:85161371345
ISSN
1042-8194
DOI
10.1080/10428194.2023.2216819
language
English
LU publication?
yes
id
7bea9be6-e245-4711-aa72-64eb7afe5bb9
date added to LUP
2023-08-24 14:42:09
date last changed
2024-09-07 14:48:46
@article{7bea9be6-e245-4711-aa72-64eb7afe5bb9,
  abstract     = {{<p>Mantle cell lymphoma (MCL) is a biologically and clinically heterogeneous disease, emphasizing the need for prognostic biomarkers. In this study we aimed at comparing the prognostic value of two RNA-based risk scores, circSCORE and MCL35, in 149 patients from the MCL2 (ISRCTN87866680) and MCL3 (NCT00514475) patient cohorts. Both risk scores provided significant stratification of high versus low risk for progression free survival (PFS) and overall survival (OS). The circSCORE retained significant prognostic value in adjusted multivariable Cox regressions for PFS, but not for OS. Furthermore, circSCORE added significant prognostic value to MIPI in the pooled cohort (MCL2 and MCL3) for PFS and OS, and for PFS in MCL3 alone, outperforming Ki67 and MCL35. We suggest a new, combined MIPI-circSCORE with improved prognostic value, and with potential for future clinical implementation, if validated in a larger, independent cohort.</p>}},
  author       = {{Salim, Ruth and Husby, Simon and Winther Eskelund, Christian and Scott, David W. and Holte, Harald and Kolstad, Arne and Räty, Riikka and Ek, Sara and Jerkeman, Mats and Geisler, Christian and Sommer Kristensen, Lasse and Dahl, Mette and Grønbæk, Kirsten}},
  issn         = {{1042-8194}},
  keywords     = {{circRNA; circSCORE; Mantle cell lymphoma; MCL35; mRNA; prognostic biomarkers}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1414--1423}},
  publisher    = {{Taylor & Francis}},
  series       = {{Leukemia and Lymphoma}},
  title        = {{Exploring new prognostic biomarkers in Mantle Cell Lymphoma : a comparison of the circSCORE and the MCL35 score}},
  url          = {{http://dx.doi.org/10.1080/10428194.2023.2216819}},
  doi          = {{10.1080/10428194.2023.2216819}},
  volume       = {{64}},
  year         = {{2023}},
}